RESUMO
The effect of α-methyl-5-hydroxytryptamine maleate, an agonist of 5-HT2B serotonin receptors, on the pumping function of the heart was examined in rats with forced motor behavior. At rest, swim-trained rats demonstrated lower HR and greater stroke volume and cardiac output than untrained rats. The agonist decreased HR, stroke volume, and cardiac output in 21- and 70-day-old swim-trained rats, but not in 100- and 200-day-old rats.
Assuntos
Coração/efeitos dos fármacos , Agonistas do Receptor 5-HT2 de Serotonina/farmacologia , Serotonina/análogos & derivados , Animais , Débito Cardíaco/efeitos dos fármacos , Coração/fisiologia , Frequência Cardíaca/efeitos dos fármacos , Ratos , Serotonina/farmacologia , Volume Sistólico/efeitos dos fármacosRESUMO
We studied cardiac pumping function in the offspring of rats subjected to swimming exercise and the offspring of untrained rats. The rat pups were adapted for swimming with stepwise increasing load from day 21 to 70 life. At the age of 21 and 70 days, offspring of trained rats showed lower HR and significantly higher stroke volume and cardiac output than offspring of untrained rats. Agonist of 5-HT(2)-receptors α-methyl-5-hydroxytryptamine maleate (30 µg/kg) reduced enhanced stroke volume in trained offspring born by trained mothers. In trained offspring of untrained rats, the agonist had more pronounced effect on HR.
Assuntos
Débito Cardíaco/fisiologia , Receptores 5-HT2 de Serotonina/metabolismo , Agonistas do Receptor 5-HT2 de Serotonina/farmacologia , Serotonina/análogos & derivados , Animais , Animais Recém-Nascidos , Débito Cardíaco/efeitos dos fármacos , Feminino , Frequência Cardíaca/efeitos dos fármacos , Condicionamento Físico Animal , Gravidez , Efeitos Tardios da Exposição Pré-Natal , Ratos , Serotonina/farmacologia , Volume Sistólico/efeitos dos fármacos , Volume Sistólico/fisiologia , Natação/fisiologiaRESUMO
The article covers results of studies concerning adenylic system state in RBC and tissues (lungs; liver, kidneys, heart, brain) of rats exposed to acute and chronic inhalation of chemical pollutants widely used in petrochemical and oil-processing industries. Findings are that the animals subjected to ecologic toxic agents have significantly decreased ATP level, ADP and AMF accumulation in tissues and RBC.
Assuntos
Nucleotídeos de Adenina/metabolismo , Poluentes Atmosféricos/efeitos adversos , Hidrocarbonetos Aromáticos/efeitos adversos , Hidrocarbonetos Clorados/efeitos adversos , Solventes/efeitos adversos , Difosfato de Adenosina/metabolismo , Monofosfato de Adenosina/metabolismo , Trifosfato de Adenosina/metabolismo , Animais , Encéfalo/efeitos dos fármacos , Encéfalo/metabolismo , Indústrias Extrativas e de Processamento , Coração/efeitos dos fármacos , Rim/efeitos dos fármacos , Rim/metabolismo , Fígado/efeitos dos fármacos , Fígado/metabolismo , Pulmão/efeitos dos fármacos , Pulmão/metabolismo , Miocárdio/metabolismo , RatosRESUMO
The paper evaluates the health status of shoe factory workers. Diseases of the nervous and cardiovascular systems, liver, gastrointestinal and respiratory tracts, and thyroid are prominent in the structure of morbidity in the workers.
Assuntos
Indústrias , Doenças Profissionais/epidemiologia , Adulto , Área Programática de Saúde , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Federação Russa/epidemiologia , Fatores de TempoRESUMO
The article covers evaluation of health state in workers of main petrochemical workshops. Leading place in structure of transitory disablement morbidity in workers is occupied by cardiovascular and nervous disorders, diseases of liver, gastrointestinal tract and respiratory system.
Assuntos
Indústria Química , Nível de Saúde , Doenças Profissionais/epidemiologia , Saúde Ocupacional , Adulto , Avaliação da Deficiência , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Morbidade/tendências , Fatores de Risco , Federação Russa/epidemiologia , Adulto JovemRESUMO
Changes in heart rate and stroke volume after successive blockade of cardiac adreno- and cholinoceptors were examined on rats of different age. It was established that irrespective of animal age the heart rate remained unchanged under conditions of total adreno- and cholinergic blockade of the heart. Stroke volume under conditions of total adreno- and cholinergic blockade increased with age.
