Evaluation in Healthy Subjects of a Transcutaneous Carbon Dioxide Monitoring Wristband during Hypo and Hypercapnia Conditions.

The development of wearable devices for healthcare monitoring is of primary interest, in particular for homecare applications. But it is challenging to develop an evaluation framework to test and optimize such a device by following a non-invasive protocol. As well established reference devices do exist for capnometry, we propose a protocol to evaluate and compare the performance of the transcutaneous carbon dioxide monitoring wristband that we develop. We present here this protocol, the signal processing pipeline and the data analysis based on signal alignment and intercorrelation study, and the first results on a cohort of 13 healthy subjects. This test allows demonstrating the influence of the device response time and of the carbon dioxide content in the ambient air.Clinical Relevance-The protocol described here allows to test and optimize the new device in clinical conditions simulating hypo and hypercapnia variations on a subject at rest, as it would be the case at home to monitor the health status of chronic respiratory patients, and to compare the performances with reference devices. A strong intercorrelation greater than 0.8 has been observed in 5 healthy subjects out of 13 and factors influencing the intercorrelation are suggested.

First Evaluation of a Transcutaneous Carbon Dioxide Monitoring Wristband Device during a Cardiopulmonary Exercise Test.

We introduce an innovative wristband wireless device based on a dual wavelength NDIR optical measurement and an optimized thermo-fluidic channel to improve the extraction of the carbon dioxide gas from the blood within the heated skin region. We describe a signal processing model combining an innovative linear quadratic model of the optical measurement and a fluidic model. The evaluation is achieved using a cardiopulmonary exercise test (CPET). We compare carbon dioxide tension measurement at the forearm level using our device, with an electrochemical measurement at the forearm level, and an optical measurement of the end-tidal exhaled breath. These curves demonstrate a significant reduction of the variability of carbon dioxide pressure measurement with respect to the pressure dynamic range during the test.