Survival time and predictors of death among HIV infected under five children after initiation of anti -retroviral therapy in West Amhara Referral Hospitals, Northwest Ethiopia.

BACKGROUND: Acquired immune deficiency syndrome is an infectious disease caused by the human immunodeficiency virus (HIV) that primarily targets an individual's immune system. In Ethiopia, nearly 24% of HIV-related deaths occur in children under the age of five. However, studies regarding the survival time of HIV-positive under-five children after anti-retroviral therapy initiation are limited with poor evidence of predictors of death. OBJECTIVE: To assess survival time and predictors of death among HIV infected under-five children after initiation of anti-retroviral therapy in West Amhara Referral Hospitals, Northwest Ethiopia, 2021. METHODS: A multicenter institution-based retrospective follow-up study was conducted among 432 HIV-positive under-five children on anti-retroviral therapy selected by simple random sampling from January 2010 to December 2019. A standardized data extraction tool was employed, which was adapted from anti-retroviral therapy entry and follow-up forms. The event of interest for this study is death, whereas the absence of experience of death is censored. Data were entered into Epi-Data version 3.1 and exported to STATA version 14. The Kaplan-Meier curve was used to estimate the survival probability. The Cox regression model was used to identify independent predictors of death. RESULTS: Among the 415 records included in the final analysis, 25 (6.02%) of the individuals were died. The incidence rate of death was found to be 2.87 per 1000 child-months (95%CI: 1.94-4.25). The cumulative survival probabilities of children after 6, 12, 24, and 36 months were 0.97, 0.95, 0.92, and 0.85 respectively. HIV-infected under-five children who lived in rural areas (AHR 3.32:-95% CI 1.17-9.39), with poor adherence to anti-retroviral therapy (AHR = 3.36; CI: 1.06, 10.69), without Isoniazide prophylaxis (AHR = 3.15; CI: 1.11, 8.94) and with anemia (AHR: 3.05, 95% CI: 1.16, 8.03) were at higher risk of death. CONCLUSION AND RECOMMENDATION: Death of HIV-infected under-five children on anti-retroviral therapy is high within the first one year after enrolment. Living in rural area, had poor adherence, lacked Isoniazide prophylaxis, and anemia were predictors of death. Therefore, clinicians shall emphasize for those specific risk factors of death and take action accordingly.

Level of Glaucoma Drug Adherence and Its Associated Factors Among Adult Glaucoma Patients Attending Felege Hiwot Specialized Hospital, Bahir Dar City, Northwest Ethiopia.

BACKGROUND: Glaucoma is a chronic optic nerve disease, often asymptomatic in an early stage, which is usually associated with elevated intraocular pressure. Good adherence to ocular hypotensive agents is essential to control the intraocular pressure and optic nerve damage. There is limited information on glaucoma drug adherence and associated factors in Ethiopia, particularly in the study area. OBJECTIVE: To determine the level of glaucoma drug adherence and associated factors among adult glaucoma patients attending Felege Hiwot Specialized Hospital, Northwest Ethiopia, 2019. MATERIALS AND METHODS: A hospital-based cross-sectional study was conducted at Felege Hiwot specialized Hospital from March 2019 to May 2019. A systematic random sampling method was used to select 402 study participants. A structured questionnaire was prepared, and adherence was assessed by using self-report questions. The collected data were entered into Epi data version 4.2.2.1 and exported into Statistical Package for Social Science version 23 for analysis. Tables, graphs, frequency, mean, and standard deviation were used for descriptive statistics. Variables with a p-value of <0.2 in the bivariable logistic regression were entered in the multivariable logistic regression, and variables with a p-value of <0.05 under multivariable analysis were taken as statistically significant factors for glaucoma drug adherence. RESULTS: Among a total of 390 study participants, 212 (56.2%) were adherent to their topical medication. Early glaucoma (AOR=2.8: 95% CI =1.29-5.91), normal vision (AOR=1.9: 95% CI=1.15-3.09), urban residence (AOR=1.6: 95% CI=1.03-2.51), family support (AOR=1.7: 95% CI=1.06-2.76) and information from pharmacist (AOR=1.8: 95% CI=1.11-2.99) were significantly associated with adherence. CONCLUSION: The level of glaucoma drug adherence was 56.2% among patients attending Felege Hiwot Specialized Hospital. Early glaucoma, normal visual acuity, family support, information on medication from the pharmacist, and urban residence were positively associated with adherence.

Educational status as determinant of men's knowledge about vasectomy in Dangila town administration, Amhara region, Northwest Ethiopia.

BACKGROUND: Although vasectomy is effective and less expensive contraceptive method, only few men are using it in Africa. The main reason for low level use may be low knowledge about vasectomy among men. Only few studies tried to investigate level of knowledge of vasectomy among married men in Ethiopia. But these studies have limitations in measuring knowledge. This study was therefore designed to assess knowledge of vasectomy among married men in Dangila town. METHOD: A community based cross sectional study was conducted in Dangila town. Sample size was calculated using OpenEPI online sample size calculator for population based surveys. Multistage sampling technique was employed to recruit the study participants. Data collectors interviewed selected men using structured Amharic questionnaire from June to July, 2014. Two days training was given to data collectors and supervisors. Data were entered and analyzed using SPSS version 16. Binary logistic regression analysis was done to identify determinants of knowledge about vasectomy. RESULT: A total of 872 men were interviewed. About 75% of men reported that they had ever heard about vasectomy. Men mentioned friends as main source of information for vasectomy. Among those who had ever heard, only 60.8% defined vasectomy correctly. About 20% defined vasectomy as "it is making the man impotent." Similarly about 16% equated vasectomy with castration. In this study, only 44.8% of men were knowledgeable about vasectomy. Married men who completed secondary education were 4.10(95%CI; 2.48 - 6.75) times more likely to be knowledgeable about vasectomy compared to those who did not attend formal education. Those who attended above secondary education were 5.73(95%CI 3.76 - 8.73) times more likely to be knowledgeable about vasectomy compared to those who did not attend formal education. CONCLUSION: Level of knowledge about vasectomy among married men in Dangla town was low and educational status was an important predictor of knowledge about vasectomy. Efforts are needed to improve knowledge of men about vasectomy. In addition, encouraging boys to complete secondary education may help improve knowledge of men about vasectomy.