RESUMO
Tumors originating from soft tissues are uncommon, among these tumors, liposarcomas are the most frequent. These tumors remain asymptomatic for a long time, and only revealing themselves when they reach an important size. In such cases, treatment is difficult, requiring extensive surgery procedures that can excise several adjacent structures, potentially completed by adjuvant radiotherapy. Despite successful treatment, the recurrence rate remains very high. We report the case of a giant liposarcoma requiring a monobloc extensive resection involving the removal of the tumor, left kidney, left adrenal gland, and a portion of the posterior abdominal wall.
RESUMO
A major challenge in cancer detection is the limited sensitivity of techniques for the initial diagnosis and subsequent monitoring of tumour evolution. Recently, many studies have focused on the discovery of molecular markers for cancer diagnosis and prognosis. One promising molecular marker for cancer detection is MN/CA9. MN/CA9 is expressed in cancers of the kidney, breast, cervix, uterus, ovary, lung, oesophagus, stomach, colon, liver, pancreas, head and neck, bladder and skin, whereas its expression in normal tissues is limited to the gastrointestinal tract, gallbladder and pancreatic ducts. MN/CA9 can be detected in cytological samples, as well as in bodily fluids, to aid in cancer diagnosis. The usefulness of MN/CA9 is also demonstrated for the detection of distant metastasis after surgery. As molecular techniques become routinely available, MN/CA9 is a powerful molecular marker in cancer diagnosis and prognosis.
RESUMO
The authors report a case of scrotal calcinosis in a 56-year-old patient. In the light of a review of the literature, they discuss the aetiopathogenic, clinical and histological features of this rare disease.
