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1.
Arch Razi Inst ; 78(1): 353-360, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-37312727

RESUMO

Interleukin-6 (IL-6) is proposed to play a significant role in pathogenesis of urinary bladder cancer (UBC). This role may be influenced by chemotherapy (mitomycin C; MMC) or immunotherapy (Bacillus Calmette-Guérin; BCG). A case-control study was conducted to determine IL-6 levels in serum of newly diagnosed cases (NDC) of superficial UBC, as well as in patients treated with MMC or BCG intravesical instillation. A total sample of 111 patients (36 NDC, 45 MMC and 30 BCG) was included, as well as a control group of 107 healthy controls (HC). IL-6 was detected by enzyme-linked immunosorbent assay. Results revealed that median levels of IL-6 were significantly elevated in NDC group (15.8 pg/mL; P<0.001) compared to MMC and BCG groups (7.5 and 5.3 pg/mL, respectively) or HC (4.4 pg/mL); while, there were no significant differences between the latter three groups (MMC, BCG and HC). Receiver operating characteristic curve analysis revealed that IL-6 is a very good predictor of UBC in NDC group versus HC (area under the curve=0.885; 95% confidence interval=0.828-0.942; P<0.001; cut-off value=10.5 pg/mL; Youden index=0.62; sensitivity=80.6%; specificity=81.3%). Logistic regression analysis confirmed this significance and IL-6 was associated with a higher risk of UBC (odds ratio=1.18; 95% confidence interval=1.11-1.26; P<0.001). In conclusion, this study indicated that IL-6 level was upregulated in serum of NDC of UBC. Further, IL-6 level was restored to normal levels after intravesical instillation of MMC or BCG.


Assuntos
Mitomicina , Neoplasias da Bexiga Urinária , Humanos , Administração Intravesical , Vacina BCG , Estudos de Casos e Controles , Interleucina-6 , Mitomicina/uso terapêutico , Neoplasias da Bexiga Urinária/tratamento farmacológico
2.
Arch Razi Inst ; 77(1): 277-284, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-35891716

RESUMO

In prediabetes, blood glucose levels are higher than normal; however, they remain below the diabetes threshold. Studies conducted on biomarkers for this disease result in controlling diabetes mellitus (DM) or reducing the risk of developing complications. Lipid profile parameters are considered important predictors of DM. Therefore, this study was conducted on three groups of normoglycemic (n=30), pre-diabetics (n=125), and diabetics (n=30) to recognize the predictive role of lipid parameters in the transition from pre-diabetes to diabetes. In this experiment, in addition to total cholesterol and triglycerides, very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride/HDL ratio, and fasting triglyceride-fasting blood glucose (FBG) index were measured. Based on the results, medians for total cholesterol, LDL, HDL, LDL/HDL ratio, cholesterol/HDL ratio, and LDL/HDL ratio did not differ significantly across the groups of normoglycemia, prediabetes, and diabetes. For triglyceride, the medians were significantly higher in pre-diabetes and also diabetes, compared to normoglycemia (i.e., 127.9 and 129.1 vs. 94.5 mg/dL, respectively [P<0.001]). Moreover, the same results were observed in the case of VLDL (i.e., 25.6 and 30.9 vs. 18.9 mg/dL, respectively). The triglyceride/HDL ratio significantly increased pre-diabetics and diabetics, compared to normoglycemic (2.72 and 2.67 vs. 2.18, respectively). Moreover, the median of the triglyceride-FBG index significantly had an increase in pre-diabetics and diabetics, compared to normoglycemic (8.89 and 9.38 vs. 8.22, respectively). The importance of triglyceride, VLDL, triglyceride/HDL ratio, and triglyceride-FBG index in distinguishing between pre-diabetes and normoglycemia was verified by a receiver operating characteristic curve analysis of the results. Logistic regression analysis confirmed the risk effects of the four parameters on pre-diabetes and diabetes. Therefore, triglyceride, VLDL, triglyceride-FBG index, and triglyceride/HDL ratio are considered promising biomarkers used to predict pre-diabetes and DM in the general population.


Assuntos
Diabetes Mellitus , Estado Pré-Diabético , Biomarcadores , Glicemia/análise , Colesterol , LDL-Colesterol , Estado Pré-Diabético/diagnóstico , Triglicerídeos , Humanos
3.
(East. Mediterr. health j).
em Inglês | WHO IRIS | ID: who-117541

RESUMO

This study investigated the association between HLA antigens and inflammatory bowel disease in 65 Iraqi patients [50 ulcerative colitis, 15 Crohn disease] compared with 67 matched controls. At HLA class I region, the patients showed significantly increased frequencies of A9 and B41 and a decrease of A11. Similar results were found when the clinical types were considered separately, except for A11, which was not significant. At HLA class II region, DR8 was significantly increased in the total patients, but the association was not maintained for ulcerative colitis or Crohn disease patients; instead Crohn disease was positively associated with DQ1. Comparing the clinical types revealed a significant difference in the antigen B16, suggesting that B16 is a differentiating marker in the disease


Assuntos
Colite Ulcerativa , Doença de Crohn , Antígenos HLA , Doenças Inflamatórias Intestinais
4.
Hum Biol ; 68(5): 755-76, 1996 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-8908800

RESUMO

Genetic polymorphisms of the complement components (five loci: C2, C3, C4A, C4B, and BF) have been investigated in the Telugu-speaking Hindu population of Hyderabad, Andhra Pradesh, India, and the Bangali-speaking Muslim population of Dacca, Bangladesh. The available data are compared to understand the genetic variation of complement components in populations of the Indian subcontinent. The C3*F and BF*F alleles show wide frequency variations in different ethnic groups of India. The range of variation in the C3*F allele is intermediate between European whites and southeast Asian populations, whereas the BF*F allele places the Indian frequencies between European whites and African blacks. This is the first population study to investigate the C2 and C4 (C4A and C4B) polymorphisms in two distinct groups of the Indian subcontinent. For the C2 polymorphism only the C2*B variant allele was observed, and its frequency was slightly higher than in European populations. In both populations the C4A and C4B loci were highly polymorphic, with a high frequency of the null alleles C4A*QO and C4B*QO, which may account for the greater susceptibility to certain autoimmune diseases in populations of South Asia.


Assuntos
Proteínas do Sistema Complemento/genética , Etnicidade/genética , Polimorfismo Genético , Bangladesh , Complemento C2/genética , Complemento C4/genética , Humanos , Índia , Funções Verossimilhança
5.
Gene Geogr ; 10(2): 93-103, 1996 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9049619

RESUMO

The distribution of four serum complement component polymorphisms (BF, C2, C3 and C4) were examined in two geographically separated populations, one from Tasmania (Australia) and the other from northeast England. The differences in genotypic frequencies between them at all 4 loci are not statistically significant (p > 0.05). When C4 haplotypes were investigated, only one (C4A4-C4B2) exhibited significant linkage disequilibrium (p = 0.0006 after correction, p = 0.01), and this was only observed in Tasmanians. The English population exhibited a larger number of alleles across the four loci used in this study than the Tasmanian, and this may well reflect a bottle-neck effect and the greater relative isolation of the population of the island State of Australia. Overall, the findings confirm the close relationship between immigrants from the British Isles to Tasmania.


Assuntos
Complemento C2/genética , Complemento C3/genética , Complemento C4/genética , Antígenos HLA-B/genética , Inglaterra , Frequência do Gene , Humanos , Fenótipo , População , Tasmânia
6.
Psychiatr Genet ; 6(2): 51-9, 1996.
Artigo em Inglês | MEDLINE | ID: mdl-8840390

RESUMO

The frequencies of HLA class I (HLA-A, B, C) and class II (HLA-DR, DQ) antigens were measured in 107 unrelated schizophrenic subjects and the results compared with 264 controls from south-east Scotland and a second control group of 133 individuals from north-east England. The expression of HLA-B35 was significantly reduced in the schizophrenic population compared to both control populations and these differences remained significant after correction for multiple testing. Linkage of schizophrenia and the major histocompatibility complex region of chromosome 6p was, however, excluded in a group of 17 families multiply affected with schizophrenia. Linkage was also excluded with several red cell antigens, red cell enzymes and plasma proteins. A negative association between the frequency of an HLA antigen and schizophrenia suggests that immune mechanisms may contribute to the aetiology of the disease in some subjects.


Assuntos
Cromossomos Humanos Par 6/genética , Antígeno HLA-B35/genética , Complexo Principal de Histocompatibilidade/genética , Esquizofrenia/genética , Adolescente , Adulto , Antígenos de Grupos Sanguíneos/genética , Proteínas Sanguíneas/genética , Suscetibilidade a Doenças , Inglaterra/epidemiologia , Feminino , Frequência do Gene , Ligação Genética , Antígeno HLA-B35/biossíntese , Humanos , Masculino , Pessoa de Meia-Idade , Esquizofrenia/epidemiologia , Esquizofrenia/imunologia , Escócia/epidemiologia
7.
J Clin Endocrinol Metab ; 70(3): 742-6, 1990 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-2307728

RESUMO

The inheritance of autoantibodies to thyroglobulin and thyroid peroxidase (thyroid microsomal antigen) has been reevaluated with newly developed ultrasensitive assays that depend on the direct interaction between antibody and radiolabeled antigen. In a study of 16 families with autoimmune thyroid disease, autoantibodies to thyroid peroxidase (TPO) were found to be inherited as a dominant Mendelian trait in females with reduced penetrance in males. Similar results were obtained with thyroglobulin (Tg) autoantibodies. Genetic linkage analysis of the loci for TPO and Tg autoantibodies with 28 polymorphic serological markers (including HLA and Gm allotypes) was carried out in 9 families. LOD scores for some serological markers (such as Gm) were uninformative, but linkage with other markers, notably the HLA antigens -A, B, -DR, -DQ, and BF on chromosome 6, could be excluded. Further studies using a comprehensive panel of gene probes to analyze DNA from families with autoimmune thyroid disease should permit the localization of the gene cluster responsible for regulating the ability to produce autoantibodies to TPO and Tg in man.


Assuntos
Autoanticorpos/genética , Genes Dominantes , Iodeto Peroxidase/genética , Tireoglobulina/genética , Tireoidite Autoimune/genética , Adolescente , Adulto , Idoso , Autoanticorpos/imunologia , Ensaio de Imunoadsorção Enzimática , Feminino , Regulação Enzimológica da Expressão Gênica , Marcadores Genéticos/análise , Humanos , Iodeto Peroxidase/imunologia , Escore Lod , Masculino , Linhagem , Tireoglobulina/imunologia , Tireoidite Autoimune/enzimologia , Tireoidite Autoimune/imunologia
8.
Ann Hum Biol ; 16(5): 443-8, 1989.
Artigo em Inglês | MEDLINE | ID: mdl-2802524

RESUMO

The polymorphisms of the complement components C2, C3, C4 and BF have been studied in a sample of 166 unrelated individuals from Northern Greece. The C3*F and BF*F allele frequencies of Greeks are within the range of frequencies reported from Europe. A single individual with a rare heterozygote variant C2C/C2A was found in Greeks. This C2*A allele was found for the first time in European Caucasoids. For the C4 system six different alleles were found at both C4A and C4B loci. There were a low frequency of the null alleles at the C4A locus and a relatively high incidence of gene duplications in this system.


Assuntos
Proteínas do Sistema Complemento/genética , Frequência do Gene , Polimorfismo Genético , Complemento C2/genética , Complemento C2a , Complemento C3/genética , Complemento C4a/genética , Complemento C4b/genética , Fator D do Complemento/genética , Grécia , Humanos , Família Multigênica
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