An Unusual Association between Sweet's Syndrome and Metastatic Papillary Follicular Thyroid Carcinoma

Sweet's syndrome (SS), or acute febrile neutrophilic dermatosis, is marked by fever, leukocytosis, and painful erythematous papules/plaques resulting from neutrophil migration and accumulation in the dermis. This condition has been associated with underlying hematologic as well as solid malignancies. We describe a unique case of SS in a patient with metastatic papillary follicular thyroid carcinoma and group A streptococcal pharyngitis. The distribution of the patient's SS rash was similar to the rash of neutrophilic dermatosis (pustular vasculitis) of the dorsal hands.

An Unusual Association between Sweet's Syndrome and Metastatic Papillary Follicular Thyroid Carcinoma

Sweet's syndrome (SS), or acute febrile neutrophilic dermatosis, is marked by fever, leukocytosis, and painful erythematous papules/plaques resulting from neutrophil migration and accumulation in the dermis. This condition has been associated with underlying hematologic as well as solid malignancies. We describe a unique case of SS in a patient with metastatic papillary follicular thyroid carcinoma and group A streptococcal pharyngitis. The distribution of the patient's SS rash was similar to the rash of neutrophilic dermatosis (pustular vasculitis) of the dorsal hands.

Actinic keratoses: past, present and future.

Actinic keratoses (AKs) are cutaneous neoplasms composed of proliferations of cytologically aberrant, epidermal keratinocytes caused by prolonged exposure to ultraviolet radiation. Combining the evidence that AKs are the second most common reason for visits to the dermatologist and it is generally believed that they should be treated, it is no surprise that the direct cost of the management of actinic keratoses in the United States (U.S.) is exceedingly high. There are currently numerous treatment modalities with more on the way as there is a demand for formulating newer, cheaper, less painful and less invasive means. The future of AK treatment involves both the continued investigation of current novel therapies, as well as the development of new treatment modalities.

Cosmeceuticals in day-to-day clinical practice.

As one of the hottest and fastest growing segments of the natural, personal care industry, Cosmeceuticals are employed to carry out numerous functions, such as preventing UV damage, reducing free radical formation, improving the skin lipid barrier, brightening and unifying skin tone, smoothing texture and reducing pore size. Vitamins and botanicals encompass a large component of the cosmeceutical market, much of which has yet to be clearly defined or regulated. It can be difficult both for the dermatologist and the consumer with respect to choosing the right regimen from the plethora of over the counter choices as well as being informed regarding potential risks and side effects. In fact, dermatologist receive minimal training with respect to this highly tapped and growing genre of topical products. There is clearly a need to research the composite active ingredients of these over-the-counter materials to further characterize their structures, develop means of deriving purified samples from clarified sources, define interactive mechanisms with the skin, and, ultimately, demonstrate efficacy and safety via evidence based means.