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1.
J Clin Rheumatol ; 27(4): 131-135, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-31743268

RESUMO

BACKGROUND/OBJECTIVE: The importance of patient-reported outcomes, like the Patient-Reported Outcomes Measurement Information System (PROMIS) measures, is increasingly recognized both in clinical care and in research. While "short forms" have been studied in juvenile idiopathic arthritis (JIA), study of PROMIS computer adaptive tests (CATs) in JIA is limited. This cross-sectional study evaluates whether PROMIS CATs correlate with disease activity in patients with JIA. METHODS: A convenience sample of patients with JIA (N = 44) was recruited from a single center. Patients and parents completed pediatric and parent proxy PROMIS CATs. Disease activity was evaluated using the Juvenile Arthritis Disease Activity Score in 71 joints (JADAS-71) and the Childhood Health Assessment Questionnaire (CHAQ). Correlation of the CAT T scores with disease activity was assessed using Spearman correlation coefficients. RESULTS: Forty-four of 80 eligible subjects (29 patients and 15 parents) completed all or some PROMIS CATs. Pain interference and mobility CATs correlated moderately with JADAS-71. Nearly all correlations with the JADAS-71 were weakened when the patient global was removed. Pain interference, mobility, and fatigue were strongly correlated with the CHAQ. Among parent proxy CATs, only mobility and depressive symptoms correlated strongly with the CHAQ. CONCLUSIONS: Only pain interference and mobility PROMIS CATs showed strong correlation with standard disease activity measures in JIA, and nearly all correlations were weakened when the patient global was removed. Correlations of the CATs with the CHAQ were stronger than correlations with the JADAS-71, indicating that although the CHAQ is no longer routinely used it may be a better measure of health-related quality of life in routine clinical care.


Assuntos
Artrite Juvenil , Artrite Juvenil/diagnóstico , Criança , Computadores , Estudos Transversais , Avaliação da Deficiência , Humanos , Medidas de Resultados Relatados pelo Paciente , Qualidade de Vida , Inquéritos e Questionários
2.
Pediatrics ; 136(1): e68-75, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26077485

RESUMO

BACKGROUND AND OBJECTIVES: Current clinical guidelines do not consider patients with rheumatic conditions to be at high risk for celiac disease (CD) despite numerous reported associations between the two in adults and children. The objective of this study was to evaluate the prevalence of CD among patients presenting for pediatric rheumatology evaluation. METHODS: A total of 2125 patients presenting for initial evaluation by the Division of Pediatric Rheumatology at the Hospital for Special Surgery between June 2006 and December 2013 were screened for CD as a part of the standard initial serologic evaluation. The charts of these patients were evaluated retrospectively at the end of this period. RESULTS: 36 patients (30 girls, 6 boys, mean age 9.4 ± 4.3 years, range 2-16 years) received a diagnosis of CD after serologic testing and evaluation by pediatric gastroenterology. Eight additional patients with known diagnoses of CD presented during this time period. The total prevalence of CD over this 6.5-year period was 2.0%. The most common presenting complaints among patients diagnosed with CD were myalgias, arthralgias, and rash. Less frequently, patients reported gastrointestinal complaints including abdominal pain, nausea, and diarrhea. All patients reported improvement or complete resolution of their musculoskeletal symptoms after initiation of a gluten-free diet. CONCLUSIONS: This study identified 36 new cases of CD among children presenting for rheumatology evaluation, for an overall prevalence rate of 2.0%. The majority of patients who ultimately received a diagnosis of CD presented with extraintestinal manifestations. These results underscore the importance of screening children presenting for rheumatology evaluation for CD.


Assuntos
Doença Celíaca/diagnóstico , Dieta Livre de Glúten/métodos , Doenças Reumáticas/diagnóstico , Adolescente , Doença Celíaca/complicações , Doença Celíaca/dietoterapia , Criança , Pré-Escolar , Erros de Diagnóstico , Feminino , Seguimentos , Humanos , Masculino , Prevalência , Estudos Retrospectivos , Doenças Reumáticas/complicações , Testes Sorológicos , Fatores de Tempo
3.
J Rheumatol ; 32(7): 1374-5, 2005 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15996084

RESUMO

Adalimumab is a fully humanized IgG1 monoclonal antibody to tumor necrosis factor-a. We describe 2 patients (17 and 13 years of age) with refractory, steroid-dependent, recurrent nonspecific orbital myositis not controlled with standard immunosuppressive medications. Both improved with adalimumab treatment, allowing reduction in corticosteroid dosage without disease flare.


Assuntos
Anticorpos Monoclonais/administração & dosagem , Pseudotumor Orbitário/tratamento farmacológico , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Adalimumab , Adolescente , Corticosteroides/administração & dosagem , Anticorpos Monoclonais Humanizados , Quimioterapia Combinada , Feminino , Humanos , Fator de Necrose Tumoral alfa/imunologia
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