Psychological inflexibility moderates the relationship between thin-ideal internalization and disordered eating.

Internalizing ideals of thinness has been related to disordered eating. Thus, it is important to identify potential protective factors that may allow someone to internalize this belief without developing an eating disorder. In this study, we explored psychological flexibility and inflexibility as potential moderators of the relationship between thin-ideal internalization and disordered eating. College women (N = 201) completed the Multidimensional Psychological Flexibility Inventory, the thin-ideal internalization subscale of the Sociocultural Attitudes Towards Appearance Questionnaire, and the Eating Attitudes Test. Psychological inflexibility, but not psychological flexibility, was found to be a significant moderator of the relationship between thin-ideal internalization and disordered eating. Further analyses found that the specific subscales which moderated this relationship were Fusion, Lack of Present Moment Awareness, Lack of Values, and Inaction. Contrary to our hypothesis, disordered eating was positively related to Acceptance. The results suggest that being psychologically inflexible is particularly problematic in the context of thin-ideal internalization. Additionally, increasing acceptance may not be effective if the accepted thoughts are about the importance of thinness.

A pilot study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16+ cervical intraepithelial neoplasia 2/3 (CIN2/3).

OBJECTIVE: The purpose of this study was to evaluate the safety, efficacy, and immunogenicity of a plasmid vaccine, pNGVL4a-CRT-E7(detox), administered either intradermally, intramuscularly, or directly into the cervical lesion, in patients with HPV16-associated CIN2/3. METHODS: Eligible patients with HPV16(+) CIN2/3 were enrolled in treatment cohorts evaluating pNGVL4a-CRT-E7(detox), administered by either particle-mediated epidermal delivery (PMED), intramuscular injection (IM), or cervical intralesional injection, at study weeks 0, 4, and 8. Patients were monitored for local injection site and systemic toxicity. A standard therapeutic resection was performed at week 15. The primary endpoints were safety and tolerability. Secondary endpoints included histologic regression and change in cervical HPV viral load. Exploratory endpoints included immune responses in the blood and in the target tissue. RESULTS: Thirty-two patients with HPV16(+) CIN2/3 were enrolled onto the treatment phase of the study, and were vaccinated. Twenty-two of 32 patients (69%) experienced vaccine-specific related adverse events. The most frequent vaccine-related events were constitutional and local injection site in nature, and were grade 1 or less in severity. Histologic regression to CIN 1 or less occurred in 8 of 27 (30%) patients who received all vaccinations and underwent LEEP. In subject-matched comparisons, intraepithelial CD8+ T cell infiltrates increased after vaccination in subjects in the intralesional administration cohort. CONCLUSION: pNGVL4a-CRT-E7(detox) was well-tolerated, elicited the most robust immune response when administered intralesionally, and demonstrated preliminary evidence of potential clinical efficacy.