A 10-year descriptive study of electroconvulsive therapy at the Neuropsychiatric Hospital, Aro, Abeokuta.

OBJECTIVES: Evidence supports the use of electroconvulsive therapy (ECT) in current practice, and good quality of care is related to adherence to evidence-based guidelines. However, there are no guidelines for the practice of ECT in Nigeria and there is no regulatory body for its standards. The objective of this study therefore was to examine the practice of ECT between 2001 and 2010 at the Neuropsychiatric Hospital, Aro, Abeokuta, regarding consent procedures, staffing, training, indications, and administration with the goal of informing the development of guidelines locally. METHODS: Data were extracted from 154 complete ECT treatment records in the register and from the patients' case files. The data were qualitatively analyzed and described. RESULTS: The mean age of patients who received ECT was 35.5 years and the majority were female. Bilateral electrode placement was invariable for all treatments. The major diagnosis of the patients receiving ECT was schizophrenia, whereas poor response to medication and psychomotor retardation were commonly stated indications. Treatments were largely unmodified during the first 3 years of the review, with a gradual reversal of this pattern in the latter years. The mean number of treatments per patient was 6.6, and only 1 patient received continuation ECT. CONCLUSIONS: Although the procedure of ECT in this center is generally similar to what is obtained in many other countries in Asia and Africa, aspects such as that of informed consent require attention. Regular audits of the practice are desirable.

Efficacy of Hibiscus sabdariffa and Telfairia occidentalis in the attenuation of CCl

Objective: To assess the efficacy of Hibiscus sabdariffa (H. sabdariffa) and Telfairia occidentalis (T. occidentalis) extracts in the attenuation of CCl

Efficacy of Hibiscus sabdariffa and Telfairia occidentalis in the attenuation of CCl4-mediated oxidative stress

OBJECTIVE@#To assess the efficacy of Hibiscus sabdariffa (H. sabdariffa) and Telfairia occidentalis (T. occidentalis) extracts in the attenuation of CCl4-mediated oxidative stress.@*METHODS@#Seventy-two healthy matured male albino rats weighing between (120±20) g were divided into 6 groups (A-F) in a 2×6 factorial experiment using completely randomized design. Rats in Group A received only water, B received 1 mL/kg CCl4, C received 300 mg/kg, D received 600 mg/kg, E received CCl4+300 mg/kg while F received CCl4+600 mg/kg for each of the extract, respectively. Semen from epididymes was obtained for sperm analysis while blood was obtained through cardiac puncture for biochemical analysis, after the treatment regimen.@*RESULTS@#Our results showed that CCl4 induction elevated aspartate aminotransferase, alanine transaminase, alkaline phosphatase, total protein, globulin levels significantly (P<0.05) while albumin was reduced. For sperm profile after CCl4 induction, sperm count, viability and motility were significant (P<0.05) reduced while sperm head abnormality increased. However, administering H. sabdariffa and T. occidentalis extracts at the doses of 300 and 600 mg/kg caused the reversal of these effects significantly.@*CONCLUSIONS@#Implicitly, the implication of our results is that H. sabdariffa and T. occidentalis extracts might be ted and optimized for the management of oxidative stress-related organ injuries, including infertility, though further researches are needed.