RESUMO
Certain industrial chemicals and food contaminants have been demonstrated to possess neurotoxic activity and have been suspected to cause brain-related disorders in humans. Acrylamide (ACR), a confirmed neurotoxicant, can be found in trace amount in commonly consumed human aliments as a result of food processing or cooking. This discovery aroused a great concern in the public, and increasing efforts are continuously geared towards the resolution of this serious threat. The broad chemical diversity of plants may offer the resources for novel antidotes against neurotoxicants. With the goal of attenuating neurotoxicity of ACR, several plants extracts or derivatives have been employed. This review presents the plants and their derivatives that have been shown most active against ACR-induced neurotoxicity, with a focus on their origin, pharmacological activity, and antidote effects.
Assuntos
Acrilamida/toxicidade , Fármacos Neuroprotetores/farmacologia , Síndromes Neurotóxicas/tratamento farmacológico , Compostos Fitoquímicos/farmacologia , Acorus/química , Monoterpenos Acíclicos , Curcuma/química , Dissulfetos , Flavonoides/farmacologia , Zingiber officinale/química , Humanos , Monoterpenos/farmacologia , Panax/química , Fitoterapia , Rosmarinus/química , Rutina/farmacologia , Alimentos de Soja , Ácidos Sulfínicos/farmacologiaRESUMO
We report two patients with malformations similar to those seen in mice with the disorganization (Ds) mutation. The first case has a body wall defect, limb malformation, and hamartoma, while the second case has a partially duplicated foot, in addition to the other anomalies. We discuss the implications that recent advances regarding the genetic analysis of the mouse Ds locus have for the search for the human homologue.
