Efficacy of Amblyopia Treatments in Children Up to Seven Years Old: A Systematic Review.

Amblyopia is a neurodevelopmental disorder of the visual system that impairs the vision of millions of children worldwide. Amblyopia is best treated within the sensitive period of visual development when a child is up to seven years of age. Currently, the gold standard for early treatment of childhood amblyopia is patching, with new treatments emerging in recent years. We aim to evaluate the effectiveness of these newly developed treatments for amblyopia in children aged seven years and younger while comparing them to the current industry standard of patching. We searched online databases including PubMed, Google Scholar, and Cochrane Library for randomized controlled trials (RCTs), systematic reviews, meta-analyses, and narrative reviews relating to amblyopia treatment in children aged seven and younger. We only included articles and studies completed within the last five years and those written in the English language. After compiling a list of 297 articles, we removed duplicates, articles without an available full text, and those not relevant to our topic. Of the remaining 51 articles, we were left with 22 after reading abstracts and removing further irrelevant articles. We did a quality assessment on the remaining 22 articles and were left with 14 articles for our systematic review after removing eight low-quality articles. Of the 14 articles, we had eight RCTs, two systematic reviews, one comparative interventional study, and three narrative reviews. Seven of the articles contained data reinforcing the effectiveness of patching while comparing it to other treatment modalities. Three of the articles had data supporting spectacle correction, including a novel form called alternative flicker glass which delivers occlusion therapy via a spectacle frame with unique lenses, and ultimately deemed it at least as effective or more than patching. Data from three articles supported the use of surgery to successfully correct the angle of strabismus. Findings from five articles backed the use of pharmacologic therapy, specifically atropine when used alongside patching as a more effective alternative to patching solely. However, levodopa plus patching had no advantage over patching alone. Additionally, seven articles addressed the use of virtual reality (VR) and dichoptic therapy as prospective treatments for childhood amblyopia. VR therapy proved beneficial when used within one week after strabismus surgery. Dichoptic training was also effective in improving amblyopic-eye visual acuity when used on its own or in conjunction with spectacles. Furthermore, dichoptic movie therapy was found to be more effective than patching. Thus, we found multiple highly effective treatments for childhood amblyopia that are as effective or more than patching. Future studies should consider prescribing these treatments to larger cohorts while also performing a cost-benefit analysis for each treatment. In addition, more needs to be learned about the potential adverse side effects of these treatments, especially for pharmaceutical therapy.

Effects of pyrolysis parameters on physicochemical properties of biochar and bio-oil and application in asphalt.

Adoption of renewable energy sources such as biomass has been increasing worldwide. In this study, fast pyrolysis as an acceptable and viable method to get renewable bio-oil and biochar is used. Different temperatures and N2 flow velocities were used in the fast pyrolysis process to evaluate the pyrolysis yield of biochar and bio-oil. The waste wood and pig manure were utilized to prepare biochar and bio-oil. X-ray fluorescence, X-ray diffraction, high-pressure liquid chromatograph, Micro confocal laser Raman spectrometer, Fourier transform infrared spectrometer, and dynamic shear rheometer were used to measure the chemical compositions, structure, and pyrolysis yield of biochar and bio-oil. The obtained results indicate that pyrolysis temperature increases the purity of inorganic oxide in biochar and N2 flow velocity promotes the yield of carbon in biochar. The increase of N2 flow velocity would increase the acid property of bio-oil and damage the products yield of bio-oil. It was also observed that biochar could remarkably alter the fundamental performances of petroleum asphalt including penetration, softening point, ductility, viscosity, and complex modulus. The most important is that the upgraded bio-oil can be used to replace partly or fully the petroleum asphalt which is a promising biomass application.

Biochar removes volatile organic compounds generated from asphalt.

Volatile organic compounds (VOCs) emission not only cause the environmental pollution, but also severely threaten human health as they are known to be toxic and carcinogenic. This study investigates the effects of biochar on removing the VOCs emission from asphalt. The biochar was obtained from the pyrolyzed productions of pig manure, waste wood and straw biomasses. Molecular model for the adsorption of the VOCs was developed and used to measure the adsorption energy and heat. The VOCs removal model was built and used to determine the VOCs removal mechanism in the asphalt. The results showed that biochar could remove alkanes, polycyclic aromatic hydrocarbons (PAHs) and sulphide compounds because of its intrinsic carbon negativity and porosity. Furthermore, source of the biochar was an influential factor on the adsorption of the VOCs compounds. Based on the results, waste wood-based biochar had the best adsorption performance which could be related to the amorphous carbon, graphite and its porous structure. Also, it shows that biochar has the great potential to be used as VOCs inhibitors.

Flow-induced crystallization of biochar in bio-asphalt under various aging conditions.

Flow-induced crystallization (FIC) in polymers is an important problem that occurs on a very rapid time scale. This study aims to evaluate the flow-induced crystallization of bio-asphalt modified with different contents of biochar under various aging conditions. Small angle X-ray scattering and molecular dynamic simulations were performed to impose extensional deformation and the nucleation process. The rheological properties were measured using the dynamic shear rheometer (DSR) and the morphology of biochar modified bio-asphalt (BMBA) was measured using an optical microscope. The relative scattering intensity during crystallization appeared to peak at four strain rates: 13.2 s-1, 19.6 s-1, 25.4 s-1, and 27.3 s-1. The results showed that the addition of biochar could improve the flow-induced crystallization and enhance the high-temperature properties of bio-asphalt. Moreover, crystallization status of BMBA is lamellar crystals. Ultraviolet and pressure aging vessel aging could remarkably affect the crystallization status of BMBA and promote the formation of crystals.

Ocular surface symptoms among individuals exposed to ambient levels of traffic derived air pollution - a cross-sectional study.

Background: The ocular surface is separated by a thin layer of tear film from outdoor air pollutants making individuals exposed to outdoor air pollution prone to various ocular surface disorders. The aim of this study was to determine the magnitude of ocular surface disorders symptoms among traffic police officers of Kathmandu, Nepal. Methods: Two hundred traffic police officers working at different traffic police office branches of Kathmandu, Nepal were invited to the police headquarters for eye and vision examination. Among them, 91 individuals (95% males) completed the ocular surface disease index (OSDI) questionnaire and underwent Schirmer's I tear test. Results: Symptoms of ocular surface disorders were reported by over 80% of the individuals. Approximately two fifths of the individuals (38%) reported severe symptoms.  Only 17% of the individuals' tear secretion was found to be below normal using the Schirmer's tear test.  There was no association between the OSDI score and Schirmer's tear test scores (r = 0.008, p = 0.94). A weak but significant relationship was observed between the OSDI score and job duration (r=0.21,p = 0.04). Individual exposed to outdoor air pollution for more than 10 years had higher odds of reporting ocular surface complaints as compared to those who were exposed for less than 10 years (OR = 3.94, p = 0.02). Conclusion: Ocular surface disorder symptoms are common among traffic police officers of Kathmandu, Nepal. The duration of exposure appears to significantly contribute to the increased symptoms in this vulnerable population.