Evaluation of efficacy and safety of adjuvant Ayurvedic therapy in patients with severe post-covid mucor-mycosis at a Government tertiary care hospital - A Case-Control study.

BACKGROUND: In the wake of the unprecedented Mucormycosis epidemic following the delta variant run second wave of SARS COV-2, the Government of Telangana decided to utilize Ayurveda for its adjuvant immune-boosting role. Based on clinical assessment of patients, Mucor mycosis was identified as Vataja vidradhi and treatment was planned. OBJECTIVE: To assess the safety and efficacy of Ayurvedic regime as an adjuvant therapy in post covid mucor mycosis patients at Gandhi Hospital, the largest Government tertiary care center in Telangana. METHODS: In this prospective case control study, 77 patients with positive or probable post covid mucor mycosis were included. The varunadi kwatha regimen could be given in very few patients precluding its meaningful analysis. 65 patients received Pancha Tikta Ghrita Guggulu [PTGG] regimen. These patients were assigned into 2 groups; Intervention [A] group n = 36, who used PTGG for a mean duration of 34.1 days and Control [B] group [drop outs] n = 29 who used PTGG for a mean duration of 2.1 days. Objective parameters like biochemical changes and parameters like disease progression, recurrence, mortality rate, subjective and objective wellbeing, readmission, repeat surgeries, and persistence of symptoms were assessed before and after treatment. Statistical analysis was done using Mann Whitney, chi square and ANOVA test. RESULTS: The Intervention group mortality rate was ZERO where as it was 13.8% in control group. The statistical analysis showed significant improvement in all clinical parameters tested. CONCLUSION: PTGG based regimen as adjuvant seemed to help across the entire spectrum of Mucormycosis. It was safe and tolerated very well with concomitant antifungal usage and in pre and post-operative patients, thus validating the host factor modification approach of Ayurveda and an integrative usage.

Focus on Ayurvedic Diet Resolves Persistent Severe Covid-19 Symptoms: Case Report.

Introduction: We report the successful management of a patient with persistent severe SARS-CoV-2 (covid-19) with poor prognosis, by using ayurvedic dietary guidelines and supporting herbal and herbomineral formulations. Case presentation: After two ICU admissions and at the end of conventional care options for Covid-19 infection, this 71-year-old patient presented online with persistent severe shortness of breath (spO2 85% on room air and spO2 75% with minimal exertion), methylprednisolone dependence of 32 mg/day, and CT Severity Score of 23/25. Upon initiating specific ayurvedic dietary guidelines (ahara) and supportive formulations to increase digestive metabolism and induce respiratory repair, the patient improved clinically (PCFS grade 4 to 2) within 3 weeks, and radiologically (CT severity 23/25 to 12/25) within 6 weeks. Conclusion: Ayurveda provides valuable clinical algorithmic insights into the mechanism of hyperinflammatory surges and dysregulated host response that characterize not only Covid-19 but also most infectious diseases. Ayurveda posits that diet incompatible with the individual's current metabolic state is the key element in inflammatory host response, providing detailed dietary guidelines, and tools that syncretize using a whole systems approach.

Understanding COVID - 19 pandemic - A comprehensive Ayurvedic perspective.

Epidemics have not been new to India. Ayurveda being in the fore front of health care of those times, has recorded its valuable experiences of epidemics & termed them as Janapadodhwamsa or Maraka. It has vividly described their mechanism of Causation (Nidana), factors affecting severity and actions complicating illnesses their management and prevention. The present work uses the same model described in Samhitas which assert the superiority of host susceptibility (Nija) over External Agent/Virus (Agantuja) and uses the same principles in prevention; while adopting the Jwara model to explain and correlate with different stages of COVID - 19. It proposes management guidelines using Ahara (Nutritional Principles) and Oushadha (Medication) for different stages and subsets of patients along with their potential complications and drug interactions, utilizing the principles of host factor modification (Dosha hara) and potential broad spectrum Anti-viral (Prativisha) as envisaged by Rasa Shastra.