RESUMO
For development of a pharmaceutical composition improving physical performance, effects of various drugs and their combinations on forced swimming test performance were studied on laboratory rats. Maximum increase in animal performance was produced by a 3-component composition asparcam+mildronate+metaprote in proportion of 5.0, 10.7, and 14.3 mg/kg, respectively. No changes in blood serum biochemistry and morphological composition of the peripheral blood were detected after single intragastric administration of the composition.
Assuntos
Antioxidantes/farmacologia , Ácido Aspártico/farmacologia , Benzimidazóis/farmacologia , Estimulantes do Sistema Nervoso Central/farmacologia , Metilidrazinas/farmacologia , Substâncias para Melhoria do Desempenho/farmacologia , Resistência Física/efeitos dos fármacos , Trifosfato de Adenosina/metabolismo , Animais , Antioxidantes/administração & dosagem , Ácido Aspártico/administração & dosagem , Desempenho Atlético , Benzimidazóis/administração & dosagem , Estimulantes do Sistema Nervoso Central/administração & dosagem , Combinação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Sinergismo Farmacológico , Ecdisterona/administração & dosagem , Ecdisterona/farmacologia , Metabolismo Energético/efeitos dos fármacos , Metilidrazinas/administração & dosagem , Substâncias para Melhoria do Desempenho/administração & dosagem , Fenitoína/administração & dosagem , Fenitoína/farmacologia , Proteínas/metabolismo , Ratos , Natação , Suporte de CargaRESUMO
The effects of 15 preparations with general tonic, antioxidant, and antihypoxant activities on exercise performance of laboratory rats were studied in the forced swimming test. The best recovery and improvement of exercise performance was recorded after a single intragastric dose of schizandrin and acyzol. These drugs stimulated an increase in the parameters in control animals by 86 and 72% (exercise performance recovery) and by 33 and 51% (exercise performance improvement).
