RESUMO
Follicular dendritic cell sarcoma is a very rare entity. So far only 12 cases have been reported world wide with involvement of tonsil. We present a new case of follicular dendritic cell sarcoma of the tonsil in a 52 years old woman with no evidence of neck node involvement. She had undergone diagnostic tonsillectomy due to unilateral tonsillar enlargement. The final diagnosis after histological review and immunohistochemical stains was follicular dendritic cell sarcoma. Bone scan showed no metastasis. One year follow-up after postoperative chemotherapy showed no evidence of local or regional recurrence. Follicular dendritic cell sarcoma is a rare and underdiagnosed neoplasm. It should be included in the differential diagnosis of any tonsillar mass in adults. Follicular dendritic cell markers such as SR-100, CD21 and/or CD35 are essential for the diagnosis.
Assuntos
Células Dendríticas Foliculares/patologia , Sarcoma/patologia , Neoplasias Tonsilares/patologia , Biomarcadores Tumorais/metabolismo , Células Dendríticas Foliculares/metabolismo , Feminino , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Sarcoma/metabolismo , Neoplasias Tonsilares/metabolismoRESUMO
OBJECTIVE: To determine the association of the Herpes Simplex virus Type-1 infection and Bell's palsy in patients treated at the outpatient department of a tertiary care center. METHODS: A prospective, observational study was carried out at the outpatient department of Medical and ENT units of Abbasi Shaheed Hospital, Karachi. Fifty patients were enrolled in the study with their informed and written consent, between 2006-2007. All were >12 years of age. They were diagnosed as having Bell's palsy and were investigated for serologic evidence of Herpes simplex virus (HSV). The IgG and IgM antibodies for HSV were identified in the blood samples at the Aga Khan University hospitals laboratory. RESULT: Of the 50 patients enrolled, 35 (70%) patients were IgG/IgM positive for the HSV stressing the etiological association of HSV with Bell's palsy. CONCLUSION: The study suggests that a relationship exists between HSV infection and Bell's palsy. The information might prove helpful in hastening the recovery by modifying management guidelines in view of the results of this study.
