Microstructural Capture of Living Ultrathin Polymer Brush Evolution via Kinetic Simulation Studies.

Performing dynamic off-lattice multicanonical Monte Carlo simulations, we study the statics, dynamics, and scission-recombination kinetics of a self-assembled in situ-polymerized polydisperse living polymer brush (LPB), designed by surface-initiated living polymerization. The living brush is initially grown from a two-dimensional substrate by end-monomer polymerization-depolymerization reactions through seeding of initiator arrays on the grafting plane which come in contact with a solution of nonbonded monomers under good solvent conditions. The polydispersity is shown to significantly deviate from the Flory-Schulz type for low temperatures because of pronounced diffusion limitation effects on the rate of the equilibration reaction. The self-avoiding chains take up fairly compact structures of typical size Rg(N) ∼ Nν in rigorously two-dimensional (d = 2) melt, with ν being the inverse fractal dimension (ν = 1/d). The Kratky description of the intramolecular structure factor F(q), in keeping with the concept of generalized Porod scattering from compact particles with fractal contour, discloses a robust nonmonotonic fashion with qdF(q) ∼ (qRg)-3/4 in the intermediate-q regime. It is found that the kinetics of LPB growth, given by the variation of the mean chain length, follows a power law ⟨N(t)⟩ ∝ t1/3 with elapsed time after the onset of polymerization, whereby the instantaneous molecular weight distribution (MWD) of the chains c(N) retains its functional form. The variation of ⟨N(t)⟩ during quenches of the LPB to different temperatures T can be described by a single master curve in units of dimensionless time t/τ∞, where τ∞ is the typical (final temperature T∞-dependent) relaxation time which is found to scale as τ∞ ∝ ⟨N(t = ∞)⟩5 with the ultimate average length of the chains. The equilibrium monomer density profile ϕ(z) of the LPB varies as ϕ(z) ∝ ϕ-α with the concentration of segments ϕ in the system and the probability distribution c(N) of chain lengths N in the brush layer scales as c(N) ∝ N-τ. The computed exponents α ≈ 0.64 and τ ≈ 1.70 are in good agreement with those predicted within the context of the Diffusion-Limited Aggregation theory, α = 2/3 and τ = 7/4.

The accuracy of transrectal ultrasound-guided biopsy for decision making in prostate cancer.

BACKGROUND: The most important surgical complications of renal transplantation are stenosis and obstruction of anastomosis of the ureter to the bladder. Hence, routine use of ureteral stents to prevent such complications seems logical; however, the optimal time to remove the ureteral stent is still controversial. OBJECTIVES: The purpose of this study was to compare the benefits and complications of the early or delayed ureteral stent removal post-transplantation. PATIENTS AND METHODS: All patients who underwent kidney transplantation in Modarres Hospital from May 2011 through March 2012 were recruited. The patients were allocated to three groups. Ureteral stent removed 10, 20, and 30 days after transplantation in groups one, two, and three, respectively. RESULTS: A total of 91 patients had undergone renal transplantation in our center. Ureteral stent was removed at 10, 20, and 30 days after surgery. Urologic complications among the three groups included hydronephrosis, urinoma, and collection around the graft; there was no statistically significant difference among study groups with regard to frequency of complications. CONCLUSIONS: We can remove the ureteral stent at shorter interval after renal transplantation with no increased risk of urologic complications.