RESUMO
BACKGROUND: Studies have reported conflicting results regarding the potential benefit of prolonged release (PR) fampridine in other domains besides walking. Moreover, only a small number of studies have explored long- term effects of PR fampridine. The aim of this study was to assess cognitive function, quality of life, mood and fatigue in MS patients treated with fampridine after 6 and 12â¯months of treatment. METHODS: IGNITE was an observational, open label study. Subjects were examined with the timed 25-ft walk (T25FW) and the BICAMS battery and were asked to complete the Multiple Sclerosis Impact Scale (MSIS-29), Modified Fatigue Impact Scale (MFIS), Beck Depression Inventory-II (BDI-II) and MS International Quality-of-Life questionnaire (MUSIQOL) at baseline and at weeks 24 and 48. Patients were sub-grouped into responders (n:40) and non-responders (n:20) according to T25FW performance after 2â¯weeks on treatment. RESULTS: After 6â¯months, statistically significant improvement was observed on T25FW (pâ¯<â¯.001), SDMT (pâ¯<â¯.001) and MSIS29 (pâ¯<â¯.001), for responders. After 1â¯year on treatment, statistically significant improvement was observed in T25FW (pâ¯<â¯.001), MSIS29 (pâ¯=â¯.004), SDMT (pâ¯<â¯.001) and MUSIQOL (pâ¯=â¯.03) for responders. There were no statistically significant improvements for the non-responders. CONCLUSIONS: PR Fampridine may have a beneficial effect on information processing speed though not on memory. Study data provide some evidence that fampridine treatment may reduce the impact of MS on daily activities and improve quality of life but has no effect on subjective fatigue and mood.
Assuntos
4-Aminopiridina/administração & dosagem , Afeto/efeitos dos fármacos , Cognição/efeitos dos fármacos , Fadiga/tratamento farmacológico , Esclerose Múltipla/tratamento farmacológico , Bloqueadores dos Canais de Potássio/administração & dosagem , Preparações de Ação Retardada , Avaliação da Deficiência , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla/psicologia , Estudos Prospectivos , Qualidade de Vida , Fatores de Tempo , Resultado do Tratamento , CaminhadaRESUMO
Central nervous system involvement is an uncommon complication of systemic non-Hodgkin lymphomas. The majority of these cases concern B-cell lymphomas. We report a case of systemic T-cell anaplastic large cell lymphoma CD30+ ALK- with CNS involvement at the time of diagnosis and unusual MRI characteristics resembling acute disseminated encephalomyelitis.
Assuntos
Encefalomielite Aguda Disseminada/complicações , Linfoma Anaplásico de Células Grandes/complicações , Quinase do Linfoma Anaplásico , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Encefalomielite Aguda Disseminada/diagnóstico por imagem , Encefalomielite Aguda Disseminada/imunologia , Encefalomielite Aguda Disseminada/patologia , Humanos , Antígeno Ki-1/imunologia , Linfoma Anaplásico de Células Grandes/diagnóstico por imagem , Linfoma Anaplásico de Células Grandes/imunologia , Linfoma Anaplásico de Células Grandes/patologia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Receptores Proteína Tirosina Quinases/imunologiaRESUMO
Bilateral internuclear ophthalmoplegia has been linked with various pathological conditions of the central nervous system (CNS), such as multiple sclerosis, stroke, tumours, and brainstem inflammatory processes. Herein the authors report a case of a 45-year-old female patient who presented with diplopia due to bilateral internuclear ophthalmoplegia, with no evidence of brainstem lesion in brain magnetic resonance imaging (MRI) and was diagnosed with primary Sjögren's syndrome.
