RESUMO
This condition was described by Haxthausen in 1934 for the first time; it is one of the diseases explained by hyperkeratosis of the palms and soles. This disease is difficult to diagnose, and patients often complain of such conditions; therefore the authors consider it useful to regularly publish descriptions of clinical cases. Besides involvement of the palms and soles, manifesting by hyperkeratotic layers, painful fissures and itching, the patients with climacteric keratoderma develop metabolic endocrine, neurovegetative, and psychoemotional disorders. When choosing the treatment strategy, the physician should bear in mind specific features of the pathogenesis and clinical picture. Earlier therapy and its efficacy are of importance, as are the presence of allergies or drug intolerance and particulars of the climacteric period course in the first- and second-degree relatives.
Assuntos
Climatério , Ceratodermia Palmar e Plantar/diagnóstico , Adulto , Feminino , Pé , Mãos , Humanos , Ceratodermia Palmar e Plantar/patologia , Pessoa de Meia-Idade , Pele/patologia , SíndromeRESUMO
A total of 2820 oilmen regularly exposed to industrial oil were examined. Folliculites were detected in 151, furuncles in 63, hydradenitis in 58, phlegmons in 35, panaritium in 30 subjects. The number of invalidity days due to pyogenic dermatoses was 2-3 times higher among the workers exposed to deep oils than among those handling surface oils; this difference is explained by chemical composition and physicochemical characteristics of the extracted oil.
Assuntos
Absenteísmo , Dermatite Ocupacional/epidemiologia , Petróleo/efeitos adversos , Pioderma/epidemiologia , Adulto , Azerbaijão/epidemiologia , Fenômenos Químicos , Físico-Química , Dermatite Ocupacional/induzido quimicamente , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pioderma/induzido quimicamente , Fatores de TempoRESUMO
Animal experiments have revealed manifest skin resorptive effect of furfural. Acute experiments have demonstrated manifest toxic action of furfural when applied to intact animal skin. Subacute action of mineral oil induced poorly manifest toxic effect manifesting as nonspecific visceral changes.
Assuntos
Furaldeído/farmacologia , Óleo Mineral/farmacologia , Absorção Cutânea/efeitos dos fármacos , Animais , Furaldeído/toxicidade , Coração/efeitos dos fármacos , Rim/efeitos dos fármacos , Dose Letal Mediana , Fígado/efeitos dos fármacos , Pulmão/efeitos dos fármacos , Masculino , Camundongos , Óleo Mineral/toxicidade , Baço/efeitos dos fármacos , Fatores de TempoRESUMO
Acute rabbit experiments have revealed furfural photodynamic characteristics. Photoprotective cream used to protect the skin from UV exposure could to a certain measure reduce the level of the photodynamic reaction developing in combined exposure to furfural and UV light. These data are recommended to be borne in mind when designing prophylactic measures.
Assuntos
Furaldeído/toxicidade , Protetores Solares/uso terapêutico , Animais , Relação Dose-Resposta a Droga , Relação Dose-Resposta à Radiação , Avaliação Pré-Clínica de Medicamentos , Pomadas , Coelhos , Pele/efeitos dos fármacos , Pele/efeitos da radiação , Fatores de Tempo , Raios Ultravioleta/efeitos adversosRESUMO
Blood serum IgG1, IgG2, IgA, and IgM were assayed by radial immunodiffusion after exposure of guinea pig skin to oil refinery products, mineral oil distillate D-11 (MOD) and furfurol (F), applied both separately and together. Application of MOD, F, and MOD + F subthreshold concentrations was found to be associated with a tendency to a reduction of IgG1 level; isolated applications of the agents in threshold concentrations involved statistically significant lowering of IgG1 (in exposure to MOD) and imbalanced levels of IgG1, IgG2, IgA, and IgM (in exposure to F). Combined application of both agents induced immunity shifts of other type as against isolated exposure.
Assuntos
Imunoglobulinas/análise , Petróleo/toxicidade , Pele/efeitos dos fármacos , Animais , Furaldeído/toxicidade , Cobaias , Imunodifusão , Óleo Mineral/toxicidade , Testes CutâneosRESUMO
Experimental multiple epicutaneous exposure of guinea pigs to furfural and D-11 mineral oil distillate and their combinations in various concentrations has resulted in structural changes of the skin and viscera. These changes were dose-dependent. Combined exposure to both agents resulted in more grave disorders than isolated exposures in the same doses.
Assuntos
Furaldeído/toxicidade , Óleo Mineral/toxicidade , Pele/efeitos dos fármacos , Administração Cutânea , Animais , Relação Dose-Resposta a Droga , Interações Medicamentosas , Cobaias , Rim/efeitos dos fármacos , Rim/patologia , Fígado/efeitos dos fármacos , Fígado/patologia , Pele/patologia , Baço/efeitos dos fármacos , Baço/patologia , Fatores de TempoRESUMO
Experimental data demonstrate a manifest skin irritating action of D-11 mineral oil distillate and furfural used in oil processing. The minimal effective concentrations of these chemicals have been defined. The irritating effects are enhanced in exposure to their combination. These data are recommended to be used when developing prophylactic measures.
Assuntos
Furaldeído/toxicidade , Óleo Mineral/toxicidade , Petróleo/toxicidade , Pele/efeitos dos fármacos , Animais , Dermatite de Contato/etiologia , Relação Dose-Resposta a Droga , Cobaias , Soluções , Fatores de TempoRESUMO
Allergenic and photosensitizing effects of organophosphorus pesticides (OPP) have been detected, as well as their destructive effect on the skin cell ultrastructure, on the body metabolism and enzymic systems, and the inhibitory effect on cholinesterase activity. Pesticide-induced changes in polyunsaturated fatty acids (PUFA) are significant in the mechanism of dermatoses development. The complex of treatment-and-prophylaxis measures includes regular dermatologic check-ups and limitation of the number of subjects handling OPP. Subjects in whom premorbid shifts have been detected, should be followed up. The therapy and prevention of the dermatoses developing as a result of exposure to pesticides may be effectively carried out with antioxidants, amino acids, vitamins, etc.; diets with the optimal PUFA-tocopherol ratio are advisable. Overalls with multiple protective physicochemical characteristics, filtering respirators and such are recommended.
Assuntos
Doenças dos Trabalhadores Agrícolas/induzido quimicamente , Dermatite Ocupacional/induzido quimicamente , Inseticidas/efeitos adversos , Compostos Organofosforados , Doenças dos Trabalhadores Agrícolas/prevenção & controle , Doenças dos Trabalhadores Agrícolas/terapia , Terapia Combinada , Dermatite de Contato/etiologia , Dermatite de Contato/prevenção & controle , Dermatite de Contato/terapia , Dermatite Ocupacional/prevenção & controle , Dermatite Ocupacional/terapia , Humanos , U.R.S.S.RESUMO
Examinations of 518 refinery workers have revealed photodermatoses in 106. The disease ran a benign course: chronic or subacute one, eventuating in hyperpigmentation and vascular maculae in the workers exposed to oil and oil products. The patients suffering from occupational photodermatoses develop immunologic shifts, i.e. reduced levels of T-cells, T-suppressors, elevated counts of B-cells and of serum immunoglobulins G and M.
Assuntos
Dermatite Ocupacional/diagnóstico , Petróleo/efeitos adversos , Transtornos de Fotossensibilidade/diagnóstico , Adulto , Formação de Anticorpos/imunologia , Azerbaijão , Doença Crônica , Dermatite Ocupacional/etiologia , Dermatite Ocupacional/imunologia , Feminino , Humanos , Imunidade Celular/imunologia , Masculino , Pessoa de Meia-Idade , Transtornos de Fotossensibilidade/etiologia , Transtornos de Fotossensibilidade/imunologiaRESUMO
Examinations of 518 refinery workers have helped define the dermatologic morbidity structure. Immunologic examinations have been carried out in 82 workers. 70 of these have developed skin abnormalities (toxicoderma, eczema, itching, hyperkeratosis, vascular spots, abnormal pigmentation, etc.). The studies have revealed reduced levels of the cell-mediated immunity parameters: T-lymphocytes, T-theophylline-sensitive lymphocytes, and decreased functional activities thereof); this has been parallelled by activation of the humoral immunity.