Problematic Use of Cannabis in Cotonou: Profile of Some Subjects Received in the Laboratory between 2016 and 2021.

Aims: The frequent use of cannabis by certain social strata often induces behavioral changes whose severity deserves to be evaluated. This study aims to describe the profile of some subjects in a situation of cannabis dependence received at the National Laboratory of Narcotics and Toxicology over the period from January 2016 to December 2021. Methodology. The approach of direct interviews with the respondents using a semistructured questionnaire made it possible to collect their sociodemographic characteristics, their experiences, and their reference trajectories. Results: A total of 48 patients, all single, with an average age of 18.13 ± 0.48 years, the majority of whom were male (77.08%) and of Beninese nationality (85.42%), were enrolled. They were pupils (58.34%), students (27.08%), and workers (14.58%). With a prevalence of consumption of 89.58%, the first experimentation of cannabis was done by imitation (83.3%), among friends (81.2%), and in schools (64.58%). The reasons for use include the search for thrills (29.20%) and the improvement of sexual energy performance (27.1%). Subjects between 64.58 and 79.17% reported having received complaints about their behavior after regular consumption of at least 3 joints of cannabis. Conclusion: The knowledge of the typical profile of subjects in a situation of dependence ensures early detection of problematic uses of cannabis and offers the opportunity to intervene a little earlier in front of this phenomenon.

Nonmedical use of tramadol among secondary school students in Benin, Africa.

Background: Nonmedical use of tramadol among the young Beninese population is an increasing public health concern. However, there is little research on tramadol use in West Africa.Objectives: This study aimed to assess the prevalence, factors associated with nonmedical use of tramadol and to determine the level of therapeutic intervention needed.Methods: A cross-sectional study design and multi-stage sampling method was used among 384 secondary school students, within the age group of 10-24 years old who gave their consent/assent. An interviewer-administered modified questionnaire based on ASSIST was administered. Urinary toxicological test was performed using NarcoCheck® quick for qualitative detection of tramadol or its metabolites. Logistic regression analysis was performed to identify factors associated with nonmedical use of tramadol.Results: The average age of our respondents was 17 ± 2 SD years old; 58.3% were males and 41.7% females. The lifetime prevalence of nonmedical use of tramadol was 9.6% (95% CI: 6.7-12.6) (13.4% males and 4.4% females) and the average age at onset was 14.8 ± 1.8 years old. Only 1.4% (n = 4) were using tramadol as shown by urine screen. Among users, 45.9% reported a hazardous level of use and required a brief intervention. In a multivariate logistic regression model, tobacco (P < .001), cannabis (p = .023) and amphetamine (p = .037) were significantly associated with nonmedical use of tramadol. The most prevalent motives for nonmedical use of tramadol was experimentation (45.9%) and the leading source for obtaining tramadol was street-level markets (86.5%).Conclusion: These results indicate that nonmedical use of tramadol affects young in Benin and represent a considerable concern among secondary school students.

HLA Class II Allele, Haplotype, and Genotype Associations with Type 1 Diabetes in Benin: A Pilot Study.

BACKGROUND: Several studies have reported the implication of HLA-DR/DQ loci in the susceptibility to type 1 diabetes (T1D). Since no such study has yet been performed in Benin, this pilot one aimed at assessing HLA class II allele, haplotype, and genotype associations with T1D. MATERIAL AND METHODS: Class II HLA genotyping was performed in 51 patients with T1D and 51 healthy unrelated controls by means of the PCR-SSP method. The diagnosis of T1D was set up according to American Diabetes Association criteria. Odds ratio (OR) and its 95% confidence interval (95% CI) were calculated to assess the associations between T1D and HLA alleles, haplotypes, and genotypes. RESULTS: Participants were aged 1-24 years. T1D was significantly associated with DR3, DQA1∗05:01, DQB1∗02:01, and DR3-DR4. No significant associations were observed with DR4, DQB1∗03:02, and DQB1∗06:02. CONCLUSION: Certain HLA class II alleles, haplotypes, and genotypes were related to T1D and may be used as genetic susceptibility markers to T1D in Benin.