Human exposure to endocrine-disrupting organochlorine and organophosphate pesticides in locally produced and imported honey in Nigeria.

The practice of exposing honeybees to pesticides by bee-keepers or via agricultural crops, is one of the ways in which honey becomes contaminated with pesticides. Though honey has many health advantages, however, human exposure to pesticides via consumption of honey has generated public health concerns due to their endocrine-disruptive abilities. Thus, this study evaluated human exposure to endocrine-disrupting pesticides in honey from Nigeria to establish the safety of honey consumed in Nigeria. Honey were analyzed for pesticides using a gas chromatograph combined with an electron capture detector. The concentrations of ∑20 OCPs and ∑14 OPPs in the honey ranged from 0.45-1045 ng/g and 1.13-632 ng/g respectively. The values of both individual and cumulative non-carcinogenic and carcinogenic risks for humans were <1 and 1 × 10-4 respectively suggesting that there are no potential health risks via the honey consumption. The source analysis showed that pesticides in these honey originated from historical and recent/fresh use.

Human exposure to organochlorine pesticides in vegetables from major cities in south-south Nigeria.

Contamination of vegetables with organochlorine pesticides (OCPs) during cultivation could affect their nutritional value and also results in adverse health effects to consumers. Thus, this study evaluates human exposure to OCPs in vegetables from major cities in south-south Nigeria. A total of eighty vegetables consisting of Vernonia amygdalina, Telfairia occidentalis, Desmodium intortum cv and Talinum triangulare obtained from four major cities (Warri, Benin, Yenagoa and Port-Harcourt) in south-south Nigeria were analysed for OCPs using a gas chromatograph coupled with a mass selective detector. The results showed that the mean concentration of ∑20 OCPs in the vegetables ranged from 11.6 to 37.7 ng g-1 fresh wt for Vernonia amygdalina, 2.48-37.0 ng g-1 fresh wt for Telfairia occidentalis, 7.63-54.2 ng g-1 fresh wt for Desmodium intortum cv and 27.3-57.3 ng g-1 fresh wt for Talinum triangulare. The concentrations of OCPs were generally lower than their respective Maximum Residue Limits (MRLs). The EDI values of the ∑20 OCPs in the vegetables ranged from 141 to 464 ng kg-1 bw day-1 for children and 26.5-87.0 ng kg-1 bw day-1 for adults. The EDI of ∑Drins, ∑Chlordanes and ∑DDTs for the vegetables were below their respective acceptable EDI values set by FAO/WHO Joint Meeting on Pesticide Residue. The hazard index values for children and adults were generally <1 suggesting that there is no potential non-carcinogenic risk for children and adults consuming the vegetables. The total cancer risk values were above 1 × 10-6 and indicated that children and adults have moderate and low carcinogenic risks respectively from ingestion of these vegetables. The isomeric ratios and principal component analysis result showed that OCPs in these vegetables originated from both historical and recent usage in vegetable cultivation.

Phthalate Esters in Tap Water, Southern Thailand: Daily Exposure and Cumulative Health Risk in Infants, Lactating Mothers, Pregnant and Nonpregnant Women.

Human exposure to phthalate esters (PAEs) via drinking water has generated public health concerns due to their endocrine disruptive abilities. This study reports on the occurrence and fate of six PAEs in raw and tap water samples collected from provincial waterworks located in Songkhla Province, Southern Thailand. In addition, the daily exposure and cumulative health risk of susceptible populations due to drinking tap water were evaluated by using four different reference dose (RfDs) sources. The maximum concentrations of PAEs in raw water were between 1.68 and 4.84 and 0.52 and 1.24 µg/L in tap water. Moreover, the levels of PAEs in the tap water samples indicated the poor PAEs removal efficiency of the conventional treatment process (59.9-69.1%). The contribution of water to the daily intake of PAEs did not exceed 0.37% in all the groups. Furthermore, both the individual and cumulative risk assessment showed negligible noncarcinogenic and antiandrogenic risk for all the groups. Nevertheless, the cumulative risk showed an increasing trend in the order of infants > lactating mothers > pregnant women > nonpregnant women, suggesting that infants are more vulnerable. In additional, the newly proposed RfDAA yielded higher hazard quotient and hazard index estimates, which indicates it is a more sensitive tool than other RfDs for the assessment of the individual and mixture risk of pollutants. The carcinogenic risk of DEHP was acceptable in every group. However, we recommend a future cumulative risk assessment of vulnerable groups considering their simultaneous exposure to all chemicals that have antiandrogenic effects via tap water.