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1.
Heliyon ; 7(11): e08404, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34901489

RESUMO

In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and bacterial infections. The present study reviewed the phytochemicals, essential oils, and pharmacological activities of O. gratissimum. The bioactive compounds extracted from O. gratissimum include phytochemicals (oleanolic acid, caffeic acid, ellagic acid, epicatechin, sinapic acid, rosmarinic acid, chlorogenic acid, luteolin, apigenin, nepetoidin, xanthomicrol, nevadensin, salvigenin, gallic acid, catechin, quercetin, rutin, and kaempfero) and essential oils (camphene, ß-caryophyllene, α- and ß-pinene, α-humulene, sabinene, ß-myrcene, limonene, 1,8-cineole, trans-ß-ocimene, linalool, α- and δ-terpineol, eugenol, α-copaene, ß-elemene, p-cymene, thymol, and carvacrol). Various in vivo and in vitro studies have shown that O. gratissimum and its bioactive constituents possess pharmacological properties such as antioxidant, anti-inflammatory, anticancer, hepatoprotective, antidiabetic, antihypertensive, antidiarrhoeal, and antimicrobial properties. This review demonstrated that O. gratissimum has a strong preventive and therapeutic effect against several diseases. The effectiveness of O. gratissimum to ameliorate various diseases may be attributed to its antimicrobial and antioxidant properties as well as its capacity to improve the antioxidant systems. However, despite the widespread pharmacological activities of O. gratissimum, further experiments in human clinical trial studies are needed to establish effective and safe doses for the treatment of various diseases.

2.
Gates Open Res ; 5: 98, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34859195

RESUMO

There has been a growing number of nutrition data visualization tools (DVTs) to monitor progress towards targets and encourage action. However, there are few documented examples of how to go about designing effective DVTs for nutrition-related audiences. In this Open Letter, we summarize reflections from collaborative efforts between the Nigeria Governors' Forum (NGF) and the Data for Decisions to Expand Nutrition Transformation project (DataDENT) in 2019-2021 to design a sub-national nutrition scorecard that aims to hold Nigeria's 36 Governors accountable to nutrition commitments. Our reflections add to an emerging body of work advocating for DVT design processes to develop a specific theory of change for how the DVT will influence target groups and achieve aims. Once the target audience is identified, it is important to create a strong engagement strategy to ensure that the DVT promotes constructive action. We also highlight the importance of identifying actionable indicators through participatory processes. We hope that these insights about collaborative DVT design can be applied by countries and institutions who want to develop similar tools to advance the nutrition agenda in their context.

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