Successful management of choroidal metastasis with intravitreal ranibizumab injections.

Uveal metastases are the most frequent intraocular malignancy in adults. Among various treatment modalities, previous studies have described intravitreal injections of bevacizumab to suppress tumor vascularity. Because of its smaller molecular size, compared to bevacizumab, ranibizumab may offer better tissue penetration and be more efficient in suppressing neovascularization in choroidal lesions. This report presents two cases of choroidal metastases from bronchial and nasopharyngeal carcinoma that were treated as a series of three intravitreal ranibizumab injections (0.5 mg each), showing definite signs of regression. The encouraging results imply that intravitreal ranibizumab may be effective in the management of choroidal metastases, but this finding will have to be confirmed by larger prospective studies.

Descemet stripping automated endothelial keratoplasty combined with phacoemulsification in Chandler syndrome.

PURPOSE: To report a case of Descemet stripping automated endothelial keratoplasty (DSAEK) in combination with phacoemulsification and implantation of intraocular lens (IOL) (triple procedure) in a patient with Chandler syndrome. METHODS: A patient with visually significant corneal edema due to Chandler syndrome and cataract underwent DSAEK combined with phacoemulsification and IOL implantation (DSAEK triple procedure). RESULTS: One year postsurgery, the patient's uncorrected distance visual acuity improved from counting fingers to 20/63, and the corrected distance visual acuity to 20/32. The cornea was clear with absence of corneal edema. CONCLUSIONS: In the presented case, DSAEK triple procedure was an effective treatment for corneal edema secondary to Chandler syndrome in the presence of cataract.