RESUMO
We present two cases of patients with systemic autoimmune diseases (one with dermatomyositis and one with CREST syndrome) who presented with a worsening of calcinosis cutis after treatment of osteoporosis with teriparatide. To our knowledge, this association is not described in the literature and might be considered in the spectrum of adverse reactions to teriparatide.
Assuntos
Conservadores da Densidade Óssea/efeitos adversos , Calcinose/induzido quimicamente , Osteoporose/tratamento farmacológico , Dermatopatias/induzido quimicamente , Teriparatida/efeitos adversos , Idoso , Síndrome CREST/complicações , Dermatomiosite/complicações , Feminino , Humanos , Pessoa de Meia-Idade , Osteoporose/complicaçõesRESUMO
We report a female patient with rheumatoid arthritis which was refractory to methotrexate, leflunomide, and anti-TNF therapy. She was treated with anti-IL-6 tocilizumab (TCZ), with an early appearance of sterile pustules on erythematous swollen skin of trunk, back, and abdominal area. The lesions were consistent with the diagnosis of acute drug-related generalized exanthematous pustulosis (AGEP). This adverse event was controlled with medical treatment without requiring removal of TCZ.
