RESUMO
No disponible
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Biotina/administração & dosagem , Biotina/metabolismo , Doenças Desmielinizantes/dietoterapia , Suplementos Nutricionais , Tireotropina/análise , Tiroxina/análise , Relação Dose-Resposta a Droga , Biomarcadores TumoraisAssuntos
Biotina/administração & dosagem , Erros de Diagnóstico , Hipertireoidismo/diagnóstico , Esclerose Múltipla Recidivante-Remitente/tratamento farmacológico , Autoanticorpos/sangue , Autoantígenos/imunologia , Biotina/fisiologia , Feminino , Doença de Hashimoto/sangue , Doença de Hashimoto/diagnóstico , Doença de Hashimoto/tratamento farmacológico , Humanos , Hipertireoidismo/sangue , Iodeto Peroxidase/imunologia , Proteínas de Ligação ao Ferro/imunologia , Pessoa de Meia-Idade , Esclerose Múltipla Recidivante-Remitente/sangue , Receptores da Tireotropina/imunologia , Estreptavidina/metabolismo , Testes de Função Tireóidea , Tireoidite Autoimune/sangue , Tireoidite Autoimune/diagnóstico , Tireoidite Autoimune/tratamento farmacológico , Tireotropina/sangue , Tiroxina/sangueRESUMO
OBJECTIVES: To investigate the effect of extreme levels of high density lipoprotein cholesterol (HDL-C) in the calculation of low density lipoprotein cholesterol (LDL-C) using Friedewald's formula (FF) and other formulas proposed recently. DESIGN AND METHODS: Lipoprotein profile was performed in 2603 samples with HDL-C ≤ 20 mg/dL and 1953 samples with HDL-C ≥ 100 mg/dL. RESULTS: Wilcoxon's and Student's t-tests showed significant differences (p<0.001) between calculated LDL-C by different formulas and direct determination in the two groups of HDL-C values. Passing-Bablok regression and Bland-Altman plot showed disagreement for the four formulas studied, except for Vujovic formula in the HLD-C ≥ 100 mg/dL group. CONCLUSIONS: Our results suggested that none of the formulas under analysis should be used for estimating LDL-C in samples with extreme HDL-C concentrations due to absence of statistical correlation with LDL-C direct measurement.
