[Clinical, biochemical and hepatic histological findings in overweight and obese Peruvian adults: first national prospective study]. / Halazgos Clínicos, Bioquímicos y de Histología Hepática en Adultos Peruanos con sobrepeso Y Obesos: Primer estudio prospectivo nacional.

We conducted a prospective, descriptive study in the Clinica Anglo Americana, a prívate institution taking care of patients from a medium-high socioeconomic level in Lima. The goal of the study was to determine the frequency of histologic findings in liver biopsies performed by laparoscopy or percutaneously in patients with overweight (body mass index > 25 kg/m2) or obesity (body mass index > 30 kg/m2), and to evaluate the correlation with antropometric variables such as BMI, waist circumference, history of diabetes or hyperlypidemia, and biochemical variables like glycemia, lipid profile, aminotransferases and AST/ALT ratio. Between the years 2001 and 2006 50 patients were biopsied, 29 with overweight and 21 with obesity. Eighteen had simple steatosis and 22 had Non-alcoholic steatohepatitis (NASH) (44%), so 40 patients (80%) had some form of fatty liver. Five patients (10%) had cirrhosis confirmed by biopsy, and in all of them the finding of cirrhosis was completely incidental. Sixty four percent of patients with NASH were obese, like the 5 cirrhotics in our series. Herein we illustrate that in a relatively small sample of patients with obesity and overweight like ours, we found all the forms of the liver steatosis spectrum, from simple steatosis to cirrhosis, with a high frequency of NASH.

Relación entre variables climáticas y casos de infección respiratoria aguda en la provincia del Callao - 2001 / Relationship between climatic variables and acute respiratory infection in the province of Callao - 2001

Objetivo: Establecer la relación entre las variables climáticas, temperatura del aire (Ta) y humedad relativa (HR), y los casos de infecciones respiratorias agudas (IRA) en la jurisdicción de la Dirección de Salud I Callao (DISA I) durante el año 2001. Material y Métodos: Estudio observacional analítico transversal. Se realizó en la Provincia Constitucional del Callao. Se recolectó la información de los casos de IRA, según las definiciones del programa de control de IRA del MINSA, de acuerdo al reporte semanal de vigilancia epidemiológica para el año 2001 de la DISA I. La información de las variables climáticas durante el año 2001, se obtuvo de la estación ChucuitoûCallao de la Dirección de Hidrografía y Navegación de la Marina. La relación entre las variables se analizó mediante correlación (coeficiente de Pearson) y regresión lineal simple y múltiple, empleando el paquete estadístico SPSS 9.0. Resultados: Durante el año 2001, se registró un total de 146 912 casos de IRA en el Callao, de los cuales 948 (0.64%) fueron Neumonía (no grave 601 y grave 347), 17 753 (12%) fueron SOB-ASMA y 128 211 (87.3%) fueron infecciones de vías superiores y bronquitis (IRA no Neumonía ni SOB-ASMA). Se encontró una correlación negativa débil entre Ta y los casos de Neumonía (r=-0.30, p=0.029), una correlación negativa moderada entre Ta y los casos de SOB-ASMA (r=-0.614, p<0.001) y una correlación negativa fuerte entre Ta y los casos de infecciones de vías superiores y bronquitis (r=-0.818, p<0.001). No se encontró correlación entre HR y los casos de Neumonía (r=0.067, p=0.640), ni entre HR y los casos de SOB-ASMA (r=0.188, p=0.180) encontrándose una correlación negativa débil entre HR y los casos de infección de vías superiores y bronquitis (r=-0.44, p=0.001). En el análisis bivariado se encontró que los cambios en la Ta explicarían el 64.8% de los casos totales de IRA (r2=64.8%, p<0.0001)...

Objective: To establish the relationship between climatic variables, air temperature (Ta) and relative humidity (RH), and the number of cases of acute respiratory infections (ARI) in the jurisdiction of the Callao Department of Health I (DISA I) for the year 2001. Methods: Observational analytical cross study that was carried out in the Constitutional Province of Callao. Information about ARI, as defined in the health ministerÆs control program, was collected from theDISA I weekly epidemiological surveillance report for 2001. The information on climatic variables during the year 2001, was obtained from the station Chucuito-Callao of the Directorate of Hydrography and Navigation of the Navy. The relationship between variables were analyzed using correlation (Pearson's coefficient) and simple linear and multiple regression using SPSS 9.0. Results: During 2001, there were a total of 146 912 cases of ARI in Callao, of which 948 (0.64%) were pneumonia (601 were no severe and 347 severe), 17 753 (12%) were SOB-ASTHMA, and 128 211 (87.3%) were upper respiratory infections and bronchitis (ARI no pneumonia or SOB-ASMA). We found a weak negative correlation between Ta and cases of pneumonia (r=-0.30, p=0.029), a moderate negative correlation between Ta and cases of SOB-ASTHMA (r=-0.614, p<0.001) and a strong negative correlation between Ta and cases of upper respiratory infections and bronchitis (r=-0.818, p<0.001). There was no correlation between HR and pneumonia (r=-0.067, p=0.640), nor between HR and cases of SOB-ASTHMA (r=-0.188, p=0.180), but a weak negative correlation between HR and cases of upper respiratory infection and bronchitis (r=-0.44, p=0.001). In the bivariate analysis we found that changes in the Ta explain 64.8% of the total cases of ARI (r2=64.8%, p<0.001). The multivariate analysis showed that changes in the Ta and in the HR explain the 65.03% of the cases of ARI (ARI cases = 6476.02 - 327.08*Ta + HR*26.73; r2 = 65.03%, p<0.001)...