Predicting Survival after Allogeneic Hematopoietic Cell Transplantation in Myelofibrosis: Performance of the Myelofibrosis Transplant Scoring System (MTSS) and Development of a New Prognostic Model.

Accurate prognostic tools are crucial to assess the risk/benefit ratio of allogeneic hematopoietic cell transplantation (allo-HCT) in patients with myelofibrosis (MF). We aimed to evaluate the performance of the Myelofibrosis Transplant Scoring System (MTSS) and identify risk factors for survival in a multicenter series of 197 patients with MF undergoing allo-HCT. After a median follow-up of 3.1 years, 47% of patients had died, and the estimated 5-year survival rate was 51%. Projected 5-year risk of nonrelapse mortality and relapse incidence was 30% and 20%, respectively. Factors independently associated with increased mortality were a hematopoietic cell transplantation-specific comorbidity index (HCT-CI) ≥3 and receiving a graft from an HLA-mismatched unrelated donor or cord blood, whereas post-transplant cyclophosphamide (PT-Cy) was associated with improved survival. Donor type was the only parameter included in the MTSS model with independent prognostic value for survival. According to the MTSS, 3-year survival was 62%, 66%, 37%, and 17% for low-, intermediate-, high-, and very high-risk groups, respectively. By pooling together the low- and intermediate-risk groups, as well as the high- and very high-risk groups, we pinpointed 2 categories: standard risk and high risk (25% of the series). Three-year survival was 62% in standard-risk and 25% in high-risk categories (P < .001). We derived a risk score based on the 3 independent risk factors for survival in our series (donor type, HCT-CI, and PT-Cy). The corresponding 5-year survival for the low-, intermediate-, and high-risk categories was 79%, 55%, and 32%, respectively (P < .001). In conclusion, the MTSS model failed to clearly delineate 4 prognostic groups in our series but may still be useful to identify a subset of patients with poor outcome. We provide a simple prognostic scoring system for risk/benefit considerations before transplantation in patients with MF.

[CHILD'S LIFESTYLE BEHAVIOURS RELATING TO WEIGHT AND MATERNAL SELF-EFFICACY IN MANAGING THEM]. / CONDUCTAS DEL ESTILO DE VIDA DEL HIJO RELACIONADAS CON EL PESO Y AUTOEFICACIA MATERNA PARA MANEJARLAS.

INTRODUCTION: parenting represents challenges. Mothers of overweight (OW) - obesity (OB) children face their children's lifestyle behaviors related to body weight. OBJECTIVES: 1) To assess the reliability of The Lifestyle Behaviour Checklist (LBC) in Spanish, 2) To evaluate the children's lifestyle behaviour that represent for the mother a problem for managing (PB) and self-efficacy (SE) to manage them in mothers of children with and without OW-OB and 3) To verify the differences between groups. METHODS: participated 367 dyads (mother / child). Mothers answered the LBC with two scales, problems behaviour scale (PBS) and self-efficacy to managing them scale (SMS). The dyads' weight and size were measured. Cronbach's alpha coefficient, descriptive statistics and ANOVA were calculated. RESULTS: Cronbach's alpha for PBS was 0.86 and 0.96 for SMS. Watches too much television was the greatest problem in managing for mothers of children with and without OW-OB (F = .232, p = .630). The mothers of children with OW-OB had lower self-efficacy compared to mothers of children without OW-OB (F = 14,155, p = .001). The mothers of children with OW-OB perceived more PB (Mean = 55.40) and less SE compared to mothers of children without OW-OB (F = 15.45, p.

Introducción: la crianza de los hijos representa retos. Las madres de hijos con sobrepeso (SP) - obesidad (OB) enfrentan conductas del estilo de vida del hijo (CEVH) relacionadas con el peso corporal. Objetivos: 1) Evaluar la confiabilidad de la escala Lista de Verificación de CEVH (LVC) en Español. 2) Evaluar las CEVH que representan un problema para su manejo (PC) y la autoeficacia (AE) para manejarlos, en madres de hijos con y sin SP-OB y 3) Verificar diferencias entre los grupos. Métodos: participaron 367 diadas (madre/hijo). Las madres contestaron la Escala LVC con dos escalas: escala problemas de conductua (EPC) y escala autoeficacia para manejarlos (EAE). Se midió peso y talla a las diadas. Se obtuvó coeficiente alpha de Cronbach, estadísticas descriptivas y se aplicó ANOVA. Resultados: el alpha de Cronbach para la EPC fue 0,86 y para la EAE 0,96. Ver mucha televisión fue el mayor PC que las madres de hijos con y sin SP-OB tienen que manejar (F = ,232, p = ,630). Las madres de hijos con SP-OB tuvieron menor AE respecto a las madres de hijos sin SP-OB (F = 14,155, p = ,001). Las madres de hijos con SP-OB percibieron más PC (media = 55,40) y tuvieron menor AE respecto a las madres de hijos sin SP-OB (F = 15,45, p < ,001). Conclusiones: la Escala LVC en Español mostró una consistencia interna aceptable. Las madres de hijos con SP-OB percibieron más PC y tuvieron menor AE. Se recomienda implementar programas para fortalecer la AE materna.

Contaminación ambiental generada por gases de combustión interna del parque automotor en la ciudad de Huánuco / Enviromental contamination generated bynternal combustion gases of the automotor park in the city of Huánuco

El trabajo se realizó con el objetivo de conocer el comportamiento del parque automotor respecto a la emisión de algunos de los principales gases contaminantes, resultado de principales gases contaminantes, resultado de la combustión interna de sus motores, como el monóxido y dióxido de carbono (co+co) y la presencia de hidrocarburos (hc) en los gases que emiten los vehículos y saber si sobrepasan los límites máximos permisibles establecidos por el ministerio de transportes y comunicaciones. Se trabajó en los puntos y áreas de mayor intensidad de tráfico vehicular previamente seleccionados. La metodología utilizada fue la descriptiva explicativa, mediante la técnica de muestreo; encontrándose que más del 66,7 por ciento de los automóviles emitían gases contaminantes por encima de los límites máximos permisibles, siendo los más criticos los fabricados antes de 1995 (85 por ciento fuera de los límites máximos permisibles); mientras que en el caso de las camionetas fabricadas antes de 1995, un 75 por ciento estaban fuera de los límites máximos permisibles, las demas mayoritariamente se encontraron dentro de los límites máximos permisibles y finalmente los trimoviles, de reciente incursión en el mercado, se encontraban de encontraban dentro de los límites máximos permisibles. Esto nos permitió determinar que la plaza de armas fue el área donde se generó la mayor cantidad de emisión de gases contaminantes, asimismo se determinaron que los puntos individuales de mayor riesgo fueron las esquinas de los jirones: Dos de mayo y Dámaso Beraúm y los jirones: Huánuco y Huallayco.

The work was carried out with the objetive or knowing the behavior of the auto motor park regarding the emission of some of the main polluting gases, result of internal combustion of its motors, as the monoxide of carbon (co), the the combination of monoxide and dioxide of carbon (co + co) and the presence of hydrocarbons (HC) in the gases that the vehicles emitted an to know if they surpassed the permissible maximum limits settled down by the ministry of transport and communications. It was worked in the points and previously selected areas of most density of vehicular traffic. The methodology used was the descriptive - explanatory, by means of the sampling technique,; It was found that they maximun limits more than 66.7 per cent of the automoviles, being the most critical those manufactured before 1995 (85 per cent outside of the permissible maximum limits); while in the case of the vans manufactured before 1995, 75 per cent was outside of the permissible maximum limits, the other ones for the most part were inside the permissible maxinum limits and finally trimoviles, of recent incursion in the marked, were within the permissible maximum limits, This allowed us to determine that the main square was the area were the biggest quantity in emission of polluting gases was generated, also it was determined that the individual points of more risk were corners of Two de mayo street and Damaso Beraúm and street and Huánuco and Huallayco streets.