Effect on ethanolic extract of sechiumedule fruitson imquimod-induced psoriasis like dermatitis in wistar rats.

The purpose of this study was to find out if the ethanolic fruit extract of Sechium edule fruits could prevent Imquimod (IMQ)-induced psoriasis-like dermatitis in male Wistar rats. The rats were divided into four groups of five rats each group. Group 1 served as a negative control, while groups 2 and 4 received 5 percent IMQ cream topically on shaved backs, topical 5 percent IMQ cream + S. edule (200mg/kg) orally once daily and topical 5 percent IMQ cream + S. edule (400mg/kg) orally once daily, respectively. From days 3 to 9, the animals treated with IMQ developed characteristic erythmea, scaling and thickening, according to the findings. Furthermore, skin thickness and the psoriasis area severity index (PASI) both were increased significantly. In IMQ-challenged mice, histological investigation revealed epidermal cuticle, including parakeratosis, acanthosis and perivascular infiltration of inflammatory cells. In IMQ-challenged rats, treatment with S. edule (200 and 400mg/kg) significantly reversed all of these symptoms.

Hepatoprotective activity of Ipomoea staphylina againsts d-glan/lps-induced acute hepatic failure in experimental rats.

The goal of this study was to see ethanolic extract of Ipomoea staphylina leaves could protect rats from D-GalN/LPS-induced AHF. Five groups (n=6) of male Wistar rats were created. Group I was given a normal control (1ml/kg); Group II was given D-GalN/LPS; Group III was given D-GalN/LPS + silymarin (100 mg/kg; p.o. ); Group IV was given D-GalN/LPS+ ethanolic extract of I. staphylina (100mg/kg); and Group V was given D-GalN/LPS+ ethanolic extract of I. staphylina (200mg/kg). All animals in groups II-V were given D-GalN/LPS (400mg/kg; and 30g/kg) on the 15th day after being treated with silymarin or I. staphylina extract for 15 days. Blood was collected from all groups of animals 24 hours after D-GalN/LPS administration to conduct biochemical analysis. The levels of SGOT, SGPT, ALP, GGT and total bilirubin in animals pretreated with the extract were all considerably lower. In addition, the total protein content was considerably greater in the extract-treated mice. The extract led to a considerable decrease in LPO levels as well as a notable increase in SOD, CAT and GSH levels in liver tissue. The extract dramatically lowered TNF-α, IL-6, iNOS, NO and MPO levels in the liver tissue.