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J Exp Biol ; 222(Pt 19)2019 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-31511344

RESUMO

Taste is essential for animals to evaluate food quality and make important decisions about food choice and intake. How complex brains process sensory information to produce behavior is an essential question in the field of sensory neurobiology. Currently, little is known about higher-order taste circuits in the brain as compared with those of other sensory systems. Here, we used the common vinegar fly, Drosophila melanogaster, to screen for candidate neurons labeled by different transgenic GAL4 lines in controlling feeding behaviors. We found that activation of one line (VT041723-GAL4) produces 'proboscis holding' behavior (extrusion of the mouthpart without withdrawal). Further analysis showed that the proboscis holding phenotype indicates an aversive response, as flies pre-fed with either sucrose or water prior to neuronal activation exhibited regurgitation. Anatomical characterization of VT041723-GAL4-labeled neurons suggests that they receive sensory input from peripheral taste neurons. Overall, our study identifies a subset of brain neurons labeled by VT041723-GAL4 that may be involved in a taste circuit that controls regurgitation.


Assuntos
Encéfalo/fisiologia , Drosophila melanogaster/fisiologia , Neurônios/fisiologia , Animais , Animais Geneticamente Modificados , Comportamento Animal , Drosophila melanogaster/genética , Feminino , Proteínas de Fluorescência Verde/metabolismo , Masculino , Optogenética , Faringe/inervação , Caracteres Sexuais , Sinapses/fisiologia , Paladar/fisiologia , Termogênese/fisiologia
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