Towards multiomic analysis of oral mucosal pathologies.

Oral mucosal pathologies comprise an array of diseases with worldwide prevalence and medical relevance. Affecting a confined space with crucial physiological and social functions, oral pathologies can be mutilating and drastically reduce quality of life. Despite their relevance, treatment for these diseases is often far from curative and remains vastly understudied. While multiple factors are involved in the pathogenesis of oral mucosal pathologies, the host's immune system plays a major role in the development, maintenance, and resolution of these diseases. Consequently, a precise understanding of immunological mechanisms implicated in oral mucosal pathologies is critical (1) to identify accurate, mechanistic biomarkers of clinical outcomes; (2) to develop targeted immunotherapeutic strategies; and (3) to individualize prevention and treatment approaches. Here, we review key elements of the immune system's role in oral mucosal pathologies that hold promise to overcome limitations in current diagnostic and therapeutic approaches. We emphasize recent and ongoing multiomic and single-cell approaches that enable an integrative view of these pathophysiological processes and thereby provide unifying and clinically relevant biological signatures.

Prevalence of Molar-Incisor Hypomineralisation in an Emerging Community, and a Possible Correlation with Caries, Fluorosis and Socioeconomic Status.

PURPOSE: To determine the prevalence of molar-incisor hypomineralisation (MIH) in 7- to 9-year-old (±1 year) schoolchildren living in Dubai, United Arab Emirates, and to find a possible association with caries, fluorosis and socioeconomic status. MATERIALS AND METHODS: In this cross-sectional study, a representative sample of 779 children with an age of 7 to 9 years ±1 year in primary schools in Dubai were randomly selected and examined by one investigator who had previously been trained and calibrated with the diagnostic criteria of European Academy of Paediatric Dentistry (EAPD) for MIH, caries diagnostic criteria of the World Health Organization (WHO) and Dean's criteria for fluorosis. RESULTS: The prevalence of MIH in Dubai was 7.57% and was almost identical for both genders (female 7.57% and male 7.58%). The caries index was high (2.41±1.7). Children with MIH in Dubai exhibited statistically significantly higher DMFT values than did children without MIH (mean 3.5 ± 1.7 vs 2.3 ± 1.7; p < 0.001). The prevalence of fluorosis was 10.9% with no statistically significant age or gender differences. CONCLUSION: The prevalence of MIH in Dubai is low. However, the caries and fluorosis values are much higher, which calls for strengthening caries-preventive efforts.