Assemblies of Copper Ferrite and Palladium Nanoparticles on Silica Microparticles as a Magnetically Recoverable Catalyst for Sonogashira Reaction under Mild Conditions.

Copper ferrite and palladium nanoparticles assembled on silica microparticles are prepared successfully and characterized by scanning electron microscopy, transmission electron microscopy, electron-dispersive X-ray analysis, X-ray diffraction, thermogravimetric analysis, atomic absorption spectroscopy, and infrared studies. The catalyst is applied effectively for the Sonogashira coupling reaction of aryl iodides and bromides under heterogeneous and phosphine-free reaction conditions. The reactions proceed at 50 °C with a low loading of palladium catalyst. The magnetically recoverable catalyst is recycled successfully for five consecutive runs with very small drops in catalytic activity.