Promoting post discharge telephone follow-up of patients with transurethral resection for bladder cancer: a best practice implementation project.

INTRODUCTION AND OBJECTIVES: Telephone follow-up (TFU) is a method that can be recommended for patients with chronic disease, including patients with nonmuscle-invasive bladder cancer (NMIBC) after transurethral resection of the bladder (TURB). This project aimed to improve postdischarge TFU of patients with TURB in a tertiary care system and referral system in Tabriz, Iran. METHODS: This evidence implementation project used the JBI evidence implementation framework. Two audit criteria were used. A baseline audit was conducted, followed by the implementation of multiple strategies. The project was finalized with a follow-up audit to evaluate changes in practice. RESULTS: The aggregated data collated from the urology ward demonstrated that all criteria had achieved 0% compliance in the baseline audit round. Strategies such as patient education about TFU, educational pamphlets developed according to the latest validated guidelines, and a mobile app for education material about bladder cancer, diagnosis, management, and follow-up were implemented. The Phase 3 follow-up showed an 88% increase in compliance with staff education about the postdischarge TFU as a component of comprehensive discharge planning and a 22% achievement of timely patient follow-up by telephone. CONCLUSIONS: A clinical audit is an effective approach to promoting postdischarge TFU in bladder cancer cases following TURB. TFU for bladder cancer patients who underwent TURB is an optimal goal that is easily achieved through patient, nursing staff, and residents' education using the latest guidelines.

Evaluation of Growth Hormone Deficiency in Children with Cystic Fibrosis.

Background: Due to chronic respiratory and gastrointestinal problems, growth failure is a common issue in patients with cystic fibrosis (CF). The present study aimed to investigate the prevalence of growth hormone deficiency (GHD) in CF children with stable gastrointestinal and respiratory conditions. Materials and Methods: In this study, the growth indicators of all 4-16-year-old children referred to two CF clinics were monitored over 3 years. Children without severe gastrointestinal or pulmonary symptoms with weight <3% percentile or whose height increase were two standard deviations below their expected height growth over 6 months were selected for the growth hormone (GH) stimulation test by clonidine and L-dopa test. Some of the children without CF, who were also referred for height growth disorders and matched the CF group, were considered the control group. They underwent the GH stimulation test, and the results were compared. Results: From 150 patients with CF, growth failure was observed in 24 patients with stable gastrointestinal and respiratory conditions; in 10 of them, the GH stimulation test was deficient. The prevalence of GHD was 6.6% in CF patients. In the control group of 30 children without CF, but with growth failure, the GH was deficient in nine cases, implying no significant difference with the case group (P = 0.37). Conclusion: In our study, the prevalence of GHD was 6.6% in CF patients, whereas the prevalence GHD in the normal population of childhood is <1%. Therefore, further studies should be designed to investigate the cause of GHD in CF patients.

Instrumented triple single-leg hop test: A validated method for ambulatory measurement of ankle and knee angles using inertial sensors.

BACKGROUND: Hop tests are commonly used in clinical environments to measure function after sport-related knee injuries. Joint angle measurement during hopping is feasible in research-based environments equipped with motion-capture systems. Employing these systems in clinical research settings is inefficient, given the associated cost, preparation time, and expertise required to administer and interpret the findings. Therefore, this study aimed to introduce a wearable system comprising three inertial measurement units for 3D joint angular measurement during horizontal hop tests, validate the joint angles against a camera-based system, and evaluate its applicability in clinical research environments. METHODS: Ten able-bodied participants were outfitted with three inertial measurement units during triple single-leg hop trials. 3D knee and ankle angles were calculated using the strap-down integration method, and results were compared with camera-based joint angles. Additionally, knee and ankle range of motions (RoMs) during bilateral triple single-leg hop trials were compared for 22 participants with unilateral sport-related knee injuries and 10 uninjured participants. FINDINGS: Estimated angles had root-mean-square and RoM error medians of less than 2.3 and 3.2 degrees for both joints, and correlation coefficients of above 0.92 when compared with the camera-based system, for all hop phases. Injured participants had smaller sagittal ankle RoM (P = .008) on their injured side, during the third hop. Concurrently, they demonstrated smaller knee RoM symmetry indices (P = .017) and injured knee sagittal RoMs (P = .009) compared to uninjured participants. INTERPRETATION: The introduced system had appropriate accuracy to highlight post-injury modifications in hopping kinematics and reveal noteworthy differences in RoM of clinical samples.

Quantification of Triple Single-Leg Hop Test Temporospatial Parameters: A Validated Method using Body-Worn Sensors for Functional Evaluation after Knee Injury.

Lower extremity kinematic alterations associated with sport-related knee injuries may contribute to an unsuccessful return to sport or early-onset post-traumatic osteoarthritis. Also, without access to sophisticated motion-capture systems, temporospatial monitoring of horizontal hop tests during clinical assessments is limited. By applying an alternative measurement system of two inertial measurement units (IMUs) per limb, we obtained and validated flying/landing times and hop distances of triple single-leg hop (TSLH) test against motion-capture cameras, assessed these temporospatial parameters amongst injured and uninjured groups, and investigated their association with the Knee Injury and Osteoarthritis Outcome Score (KOOS). Using kinematic features of IMU recordings, strap-down integration, and velocity correction techniques, temporospatial parameters were validated for 10 able-bodied participants and compared between 22 youth with sport-related knee injuries and 10 uninjured youth. With median (interquartile range) errors less than 10(16) ms for flying/landing times, and less than 4.4(5.6)% and 2.4(3.0)% of reference values for individual hops and total TSLH progression, differences between hopping biomechanics of study groups were highlighted. For injured participants, second flying time and all hop distances demonstrated moderate to strong correlations with KOOS Symptom and Function in Daily Living scores. Detailed temporospatial monitoring of hop tests is feasible using the proposed IMUs system.

Comparison of Stress Distribution in Alveolar Bone with Different Implant Diameters and Vertical Cantilever Length via the Finite Element Method.

Available bone is one of the important factors in implant treatments. Due to concerns about complications caused by less bone implant contact area, researchers have focused on biomechanical properties of implants and methods to promote them. We investigated stress distribution around bone of different implant diameters and vertical cantilever length. Computed tomography (CT) images obtained of human mandible were used in this study. An SPI implant (Alpha Bio Tech, Simplantology) of two different lengths (10.5 mm and 8.5 mm) and two different widths (3.5 mm and 4.5 mm) were placed into two different groups of bone samples (with and without osteoplasty). Vertical and lateral forces of 100N and 30N at 45° were applied simultaneously in two models. The stress was analyzed using the finite element method. Maximum stress areas were located around the implant neck. Lower stress values in the loaded implants were observed in the shorter group related to the increase in crown height space, when compared to the other group. A wider implant may be better to dissipate force, thus reducing stress on the bone surrounding the implant. Additionally, the use of shorter and wider implants might be a reasonable alternative in sites limited by the height of the residual ridge.

Sensor-to-body calibration procedure for clinical motion analysis of lower limb using magnetic and inertial measurement units.

Magnetic and Inertial measurement units (MIMUs) have become exceedingly popular for ambulatory human motion analysis during the past two decades. However, measuring anatomically meaningful segment and joint kinematics requires virtual alignment of the MIMU frame with the anatomical frame of its corresponding segment. Therefore, this paper presents a simple calibration procedure, based on MIMU readouts, to align the inertial frame of the MIMU with the anatomical frames, as recommended by ISB. The proposed calibration includes five seconds of quiet standing in a neutral posture followed by ten consecutive hip flexions/extensions. This procedure will independently calibrate MIMUs attached to the pelvis, thigh, shank, and foot. The accuracy and repeatability of the calibration procedure and the 3D joint angle estimation were validated against the gold standard motion capture system by an experimental study with ten able-bodied participants. The procedure showed high test-retest repeatability in aligning the MIMU frame with its corresponding anatomical frame, i.e., the helical angle between the MIMU and anatomical frames did not significantly differ between the test and retest sessions (except for thigh MIMU). Compared to previously introduced procedures, this procedure attained the highest inter-participant repeatability (inter-participant coefficient of variations of the helical angle: 20.5-42.2%). Further, the proposed calibration would reduce the offset errors of the 3D joint angle estimation (up to 12.8 degrees on average) compared to joint angle estimation without calibration (up to 26.3 degrees on average). The proposed calibration enables MIMU to measure clinically meaningful gait kinematics.