RESUMO
The percentage of overweight and obese person has increased markedly since several decays. Obesity is associated with increased risked factor for many diseases such as, diabetes, heart complications, arthritis and certain types of cancer. Feeding behavior is in controlled by a major interaction between central nervous system and many organs of the body. The role of serotonin (5-HT) in feeding behavior is well recognized. The aim of present study was to evaluate the effect of Anethum graveolens seeds aqueous extract (AGAE) on food intake, body weight and serotonin metabolism in over weight rats. Five weeks oral administration of AGAE shows significant decrease in body weight, food intake and significant increase in whole brain 5-HT, 5-HIAA and tryptophan level in brain and plasma of experimental animals. Increased level of 5-HT induced satiety and suppressed food intake and result is the reduction in body weight.
Assuntos
Anethum graveolens , Fármacos Antiobesidade/farmacologia , Comportamento Animal , Encéfalo/efeitos dos fármacos , Comportamento Alimentar/efeitos dos fármacos , Obesidade/tratamento farmacológico , Extratos Vegetais/farmacologia , Sementes , Serotonina/metabolismo , Redução de Peso/efeitos dos fármacos , Administração Oral , Anethum graveolens/química , Animais , Fármacos Antiobesidade/administração & dosagem , Fármacos Antiobesidade/química , Fármacos Antiobesidade/isolamento & purificação , Encéfalo/metabolismo , Encéfalo/fisiopatologia , Modelos Animais de Doenças , Ingestão de Alimentos/efeitos dos fármacos , Ácido Hidroxi-Indolacético/metabolismo , Masculino , Obesidade/metabolismo , Obesidade/fisiopatologia , Obesidade/psicologia , Fitoterapia , Extratos Vegetais/administração & dosagem , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Plantas Medicinais , Ratos Wistar , Fatores de TempoRESUMO
Use of the herbal drugs increasing all over the world due to its minimum side effect. Nigella sativa black seeds used in folk medicine for the promotion of good health and for the treatment of many diseases .The present study is designed to investigate the neurochemical and behavioral effect of aqueous extract of Nigella sativa L. seeds in rats. Neurochemical studies were performed for DA and DOPAC levels in whole rats' brain. Locomotive behavior was observed in novel environment and familiar environment. Elevated plus maze and light dark behavioral modules were used to monitor anxiety in rats. The oral administration of AENS for six weeks increased time spent in open arm of elevated plus maze and light compartment in light dark box. Increased locomotors activity in novel environment (open field) was noticed suggesting that increased in DA level may be related to increased locomotive activity in rats.
