[The psychological characteristics of adolescents with ischemic heart disease in their anamnesis and their linkage to the lipoprotein spectrum indices]. / Psikhologicheskie osobennosti podrostkov s ishemicheskoi bolezn'iu serdtsa v anamneze i ikh sopriazhennost' s pokazateliami spektra lipoproteidov.

A psychological survey (MMPI, Wolff, Rosenzweig, Spielberger, Eysenck tests) of 70 adolescents with family history of coronary heart disease established the following personality traits in them: activity, leadership inclinations, extroversion, impulsiveness, heteroaggressiveness coupled with inner strain, anxiety. The anxiety, heteroaggression, extroversion correlated with atherogenic changes in lipoprotein spectrum.

[Changes in central hemodynamics as a risk factor of the development of ischemic heart disease in adolescents with aggravated heredity of atherosclerosis]. / Izmenenie tsentral'noi gemodinamiki kak faktor riska razvitiia ishemicheskoi bolezni serdtsa u podrostkov s otiagoshechennoi nasledstvennost'iu po aterosklerozu.

The authors provide the data on the central hemodynamics, blood plasma lipoproteins and apoproteins in 101 adolescents with aggravated heredity as regards coronary heart disease and in healthy adolescents of the same age serving as control. The hypokinetic variant of circulation is demonstrated to be coupled with the atherogenic nature of the lipoprotein and apoprotein spectra and heredity to contribute greatly to the traits under study. Criteria for the adolescents' inclusion into the group at the highest risk for early development of atherosclerosis are described.

[Incidence among men of atherogenic potential of the serum detected in a culture of mouse peritoneal macrophages]. / Rasprostranennost' sredi muzhchin aterogennogo potentsiala syvorotki krovi, vyiavliaemogo v kul'ture peritoneal'nykh makrofagov myshi.

Blood serum of 63 persons out of 191 men examined, randomly selected among non-organized population, caused in primary culture of mice peritoneal macrophages the 1.3-4-fold increased accumulation of intercellular cholesterol. Blood serum of other 128 men studied did not exhibit any atherogenic properties in the culture. The atherogenic potential of blood serum did not correlate with content of blood serum lipids, apolipoproteins B and A-I, while it correlated with the ratio apo B/apo A-I in blood serum and with one of ischemic heart disease risk factors--increased arterial pressure. Blood serum atherogenic potential, detected in experimental model, appears to be involved in development of human atherosclerosis.

[Atherogenic dyslipidemia in adolescents: its relation to ischemic heart disease in their fathers and the possibility of its prognosis]. / Aterogennye dislipidemii u podrostkov: svia'z s nalichiem ishemi- cheskoi bolezni serdtsa u ottsov, vozmozhnos't prognozirovaniia.

Comparison of a group of adolescents aged 11-16 years whose fathers had angiographically documented coronary atherosclerosis in youth with those matched by sex and age whose parents were clinically healthy yielded the following discriminant function (DF) involving lipid and apoprotein indices of the plasma lipid system: DF = [apo B] X 0.03-[HDL cholesterol] X 0.04-0.81. DF greater than or equal to 0 discriminates from the controls 32% of the offsprings from the fathers with a history, DF less than 0 correctly classifies 98% of adolescents from the controls. The adolescents who have DF greater than or equal to 0 amounted to about 19% in representative samples of Moscow adolescents. Moreover, DF with 80% probability makes it possible to predict the time course of serum lipid levels in adolescents within 2 years.

[Role of genetic and environmental factors in determination of arterial blood pressure level]. / Rol' geneticheskikh i sredovykh faktorov v determinatsii urovnia arterial'nogo davleniia.

Three groups of families with different initial levels of arterial pressure in proband children were examined. The relationship was established between the levels of arterial pressure in children and those in their relatives of the first degree of kinship. Based on intrafamilial correlations, the phenotypic dispersion of systolic and diastolic arterial pressure was analyzed. It has been shown that as compared to the genetic factors, the environmental factors play a greater role in arterial pressure variability.

[Changes in phospholipid composition of high density lipoproteins in children as a possible precursor of the development of ischemic heart disease]. / Izmenenie fosfolipidnogo sostava lipoproteidov vysokoi plotnosti u detei kak vozmozhnyi predvestnik razvitiia ishemicheskoi bolezni serdtsa.

The proportion of apoprotein-AI (apo-AI) phospholipids (PL) and HDLP phospholipid spectrum were determined in addition to principal coronary risk factors; cholesterol (CS), triglycerides (TG) and high-density lipoprotein (HDLP) CS, in high-risk children, whose parents had survived myocardial infarction at a young age, and also in children with vegetovascular dystonia and a control group. It is demonstrated that children with relatively low percentage of lecithin in HDLP, in the absence of changes in CS, TG, apo-B and apo-AI, and HDLP CS, could be found in all the examined groups, and were particularly numerous in the high-risk group. Correlations coefficients for the HDLP PL percentage in the father-child, mother-child and father-mother pairs were estimated, revealing a positive correlation with respect to lecithin in these pairs, an evidence of the contribution of the general familial environment to the variability of the parameter in question in the examined groups. Different correlations were demonstrated between lecithin/sphingomyelin and lecithin/kephalin ratios in boys and girls from the control and high-risk groups.

[Characteristics of hemostasis, fibrinolysis and lipid indicators in children and their fathers with a history of myocardial infarction at a young age]. / Kharakteristika gemostaza, fibrinoliza i pokazatelei lipidov u detei i ikh ottsov, perenesshikh infarkt miokarda v molodom vozraste.

Blood coagulation and fibrinolysis characteristics are described in children whose fathers survived myocardial infarction when fairly young. Hemostatic and fibrinolytic effects of heredity are analysed, as are lipid spectrum disorders. Children with aggravated heredity showed changes in plasma fibrinogen concentration, antithrombin III, total plasma fibrinolytic activity recalcification time. The monitoring of children with aggravated heredity for coronary heart disease, particularly those with attendant dyslipoproteinemia as a specific high-risk group, is proposed.

[Lipids and apoproteins in the blood plasma of children with a hereditary disposition to ischemic heart disease]. / Lipid i apoproteiny v plazme krovi detei s nasledstvennoi predraspolozhennost'iu k ishemicheskoi bolezni serdtsa.

An investigation of children with aggravated heredity (coronary disease), and those with vegetovascular dystonia whose parents had no clinically apparent coronary disease demonstrated unidirectional shifts in the lipoprotein system of the two samples as compared to the controls: increased cholesterol levels in low-density lipoproteins and lowered cholesterol in high-density lipoproteins and apoprotein A1. In children with aggravated heredity, these changes are also associated with vegetovascular dystonia, whereas in the absence of the latter they are not apparent or minimal. At the same time, certain differences in cholesterol distribution over lipoprotein fractions and protein/lipid ratios suggest that mechanisms of changes are not identical in children with aggravated heredity and those free from it.

[Retardation of psychomotor development in children during the first year of life]. / Osobennosti zaderzhki psikhomotornogo razvitiia u detei pervogo goda zhizni.

Many-year observations of 1680 children with retarded psychomotor development during the first year of life suggest that qualitative and quantitative differentiation of the development retardation should be made. Two variants of psychomotor development retardation in children of the first year of life are distinguished: a benign nonspecific, and a specific one. In the former case, the retardation is not due to a specific damage to the brain or its dysfunction, i. e. at the basis of this retardation there lie a delayed maturation of the brain structures and a slower development of their functions without qualitative changes in the nervous system. The specific retardation is always due to a damage to the brain structures and their functions. In this variant there is a dysfunction of the brain which manifests in various neurological syndromes. The authors explain the peculiarities of the nonspecific and specific retardation at various age periods, give examples of the differentiation of the specific retardation with regard to its gravity, and describe the principal neurological syndromes characterizing this retardation.

[Role of complex studies in the diagnosis of spinal amyotrophy in young children]. / Znachenie kompleksnykh issledovanii dlia diagnostiki spinal'nykh amiotrafii u detei rannego vozrasta.

The analysis of a pathomorphological verified case of Werding-Hoffmanns disease and its comparison with the other clinical and EEG data shows that the specific electromyographical traits of the spinal lesion in some patients are revealed in a late period. For the differentiation of the essential muscular and the secondary neurogenic lesions in the early stages of the disease the morphological studies of muscular bioptic specimens are very important.