[Atypical forms of duodenal ulcer]. / Las formas atípicas de la úlcera duodenal.

In view of the lack of studies on the percentage of atypical forms of duodenal ulcer, we made one based on our cases, analyzing separately the location, hours and time periods. We personally studied 3,120 duodenal ulcers, considering as atypical those that diverged form the norm in any of the 3 variables. The epigastrium was considered to be the characteristic location, extending from the infraxiphoid zone to the navel, although there can be simultaneous pain in other abdominal zones, the breast or back. The hour was found to be more than an hour after the feeding. Time intervals of more than 2 months without discomfort were established and the pain intervals lasted from 10 days to 2 months. Complicated ulcers were not considered. Atypical duodenal ulcers represent more than a fourth, 27.37%. Of the three variants, one the most common and three were less frequent. The absence of pain during determined time periods in more than two thirds is emphasized, while those without a pattern of hours and of atypical location are more or less equal. We note that the absence of determined time periods represents 80% of atypical duodenal ulcers and a fifth of all duodenal ulcers.

Lipolysis by corticotropin in fat cells from hypothyroid rats. Effect of adenosine deaminase.

Thyroid hormones are required for maximal stimulation of lipolysis of fat cells by catecholamines corticotropin and glucagon. Several reasons have been given to explain this fact, but all of them are controversial and still not definitive. It has been proposed that adenosine is an important factor in the low lipolytic response to catecholamines by fat cells of hypothyroid rats. This proposal has been studied with corticotropin. There has been no recuperation of maximal lipolysis when fat cells of hypothyroid rats were stimulated by corticotropin in the presence of adenosine deaminase.

Action of a water soluble splenic material on anaesthetized rat blood pressure.

The effects of a biologically active water-soluble splenic material on the rat blood pressure are described. The endovenous perfusion of the splenic material in acidified and alkalinized forms caused significant increases of the mean blood pressure in normal, vagotomized and pithed rats, showing that, in contradiction to previous reports, changes in pH did not affect its hypertensive activity. In normal rats, the hypertensive responses were not affected by the alpha- and beta-adrenoceptor antagonists: tolazoline, ergotoxine and propranolol, supporting the previously stated view that adrenergic mechanisms are not involved. In addition, the aforementioned results obtained in vagotomized and pithed rats suggest a lack of involvement of cardiac and vascular nervous mechanisms.

[Incorporation of 1-C14 palmitic acid into liver lipids of rats in different hormanal states]. / Incorporación de 1-C14 ácido palmítico a lípidos hepáticos de rata en diferentes estados hormonales

Adrenalectomy and/or cortisol-induced variations in the in vivo and in vitro incorporation of 14C-palmitic acid 1 into the different fractions of rat liver lipids were studied. The different fatty acids incorporations follow analogous patterns in every hormonal state in vitro. Incorporation rate is faster in normal animals, but adrenalectomy or the administration of cortisol produces a marded delay. Cortisol does not modify the anomalism observed in the adrenoprival state. In vivo, the incorporation of palmitic acid into the different liver lipids--for the same hormonal state--does not follow the same pattern.

[Effects of adrenalectomy and cortisol administration on the concentration of free fatty acids, triglycerides and total lipids on the liver of rats]. / Efectos de la adrenalectomía y de la administración de cortisol sobre las concentraciones de ácidos grasos libres, triglicéridos y lípidos totales en hígado de rata

The hepatic concentration of triglycerides, free fatty acids and total lipids was determined in four groups of rats: normals, adrenectomized and normal and adrenectomized previously treated with cortisol, 30 mg. In chronic adrenectomized state, total lipids and hepatic triglycerides are diminished, particularly the triglycerides. Adrenectomy does not appear to have significative effect on the free fatty acids. The administration of cortisol does not change those observations and, when given to normal animals, decreases the hepatic concentrations of free fatty acids, triglycerides and total lipids.

[Effect of adrenalectomy and the administration of cortisol on plasma and liver cholesterol free and esterified in rats]. / Efectos de la adrenalectomía y de la administración de cortisol sobre el colesterol (libre y esterificado) en plasma e hígado de rata

The effect of cortisol on the levels of free and sterified cholesterol in the livers of normal and adrenectomized rats has been studied. The results indicate that cortisol enhances those lipids in plasma and decreases their level in the liver.