[Structuro-functional changes in lymphoid populations during the course of carcinogenesis]. / Izuchenie strukturno-funktsional'nykh izmenenii limfoidnykh populiatsii v dinamike kantserogeneza.

A comparative study was made of the percentage of cells bearing the receptor for the third component of the complement (LRC) and of the total cell content in the rat lymphoid organs as related to the time course of cancerogenesis. It was shown that impairment of the maturation processes in the thymus and in the peripheral organs (lymph nodes, blood) of the immunocompetent systems produces changes in intercellular interactions, reflected by accumulation of B cells, i. e. LRC, and their delayed maturation to antibody producers.

[Analysis of the effect of morphine on the reproductive capacity and immunological status of mice]. / Analiz deistviia morfina na reproduktivnuiu sposobnost' i immunologicheskii status myshei.

Embryogenesis process is disturbed under the action of prolonged morphine administration to CBA mice. Simultaneously a decrease in the level of antibody-synthesizing cells and a significant reduction in the cooperating interaction of T and B lymphocytes in response to the injection of sheep red blood cells are noted. At the same time stimulation of bone marrow cells and specific sensitization of MIF-inducers to the antigen from the brain of morphinized mice are revealed.

[Use of the enzyme neuraminidase for immunotherapeutic treatment of chemically induced carcinogenesis]. / Ispol'zovanie fermenta neiraminidazy dlia immunoterapevticheskogo vozdeistviia na khimicheski indutsirovannyi kantserogenez.

The effect of vibrio cholerae neuraminidase (VCN) on the growth of dimethylbenzanthracene-induced sarcoma cells in the inbred CBA mice was investigated. The use of this preparation was started after the appearance of the tumour. Injection of 50 units of VCN twice a week for three months was effective at the early stages of carcinogenesis. An increase of the life-span of mice of comparison with control animals was also observed in the animals inoculated intraperitoneally with induced syngeneic sarcoma cells pretreated with VCN and simultaneously injected (into the developing tumour) with sensitized lymphocytes received from the syngeneic tumour-bearing mice. Lymphocytes were inoculated into the growing tumour. No positive effect ensued when the lymphocytes inoculated into the tumour region were pretreated with VCN. A simultaneous inoculation of neuraminidase into the growing tumour and of syngenous induced-sarcoma cells pretreated with this enzyme intraperitoneally was the most effective. Possibilities of application of neuraminidase under clinical conditions are discussed.

[Changes in the immunologis status of the body during carcinogenesis detected by the physico-chemical characteristics of cells of the immunocompetent system]. / Izmeneniia immunologicheskogo statusa organizma pri kantserogeneze, vyiavliaemye po fiziko-khimicheskim kharakteristikam kletok immunokompetentnoi sistemy

The state of cell population of the lymph nodes and the thymus was studied on a model of rat sarcoma of the hip(induced by dimethlbenzanthracene) by the method of fluorescent sounds. Statistically significant changes of incorporation of the negatively charged sound 1-anilino-8-naphthalinosulfonate (ANS) into cell suspension, depending on the stage of sarcoma development, were detected. The appearance of cell forms with a lesser hydrophobic character of the surface and with less binding points for the ANS were noted at the early carcinogenesis periods. It is supposed that these cells were referred to immature ones. A conclusion was drawn on the applicability of the method of fluorescent sound for recording changes in the immunological state of the organism in carcinogenesis.

[Enzymatic and immunologic activity of lymphocytes during chemical carcinogenesis]. / Izuchenie fermentativnoi i immunologicheskoi aktivnostei limfotsitov pri khimicheskom kantserogeneze

The activity of acid phosphatase and some dehydrogenases in the peripheral blood lymphocytes was compared with the development of cell immunity, assessed by the macrophage migration inhibition test, during chemical carcinogenesis in Wistar rats. At the early stages of the carcinogenesis the changes of the enzymatic activities of succinic dehydrogenase and acid phosphatase proved to coordinate with a sufficiently high level of the immunological reactivity of the cell type in 66% of the animals. With the progressive growth of the tumours there occurred a disturbance of the enzymatic balance in the lymphoid cells and a simultaneous decrease in the immunological response.