[Functional status of the pituitary-thyroid system in children and adolescents exposed to radiation as a result of the accident at the Chernobyl Nuclear Power Station]. / Funktsional'noe sostoianie gipofizarno-tireoidnoi sistemy u detei i podrostkov, podvergshikhsia radiatsionnomu vozdeistviiu v rezul'tate avarii na Chernobyl'skoi AES.

The paper is concerned with the results of a follow-up over the period of 1986-1989 of function of the hypophyseo-thyroid system in children and adolescents (approximately 6000 persons), residing in the South-West of the Kaluga Region, where radiation fallouts were observed after the Chernobyl accident. The results were based upon the analysis of medical examinations and determination of the blood levels of TSH, T4 and T3. A certain functional activation of the thyroid system was observed in a majority of the examinees. A conclusion has been made of a necessity of a long-term follow-up of the thyroid of persons who received radioactive iodine in childhood.

[Mathematical models in clinical radiobiology and optimization of the radiotherapy of tumors]. / Matematicheskoe modelirovanie v klinicheskoi radiobiologii i optimizatsiia luchevoi terapii opukholei.

A mathematical model was developed in the system of tumor-normal tissues. It reflected the main radiobiological factors and regularities of tumor growth kinetics: heterogeneity of cell populations with relation to radiosensitivity and a tendency to proliferation, the effects of reoxygenation. Using a package of RADON applied programs optimum irradiation regimens were obtained simultaneously for single doses and intervals of interfractional recovery. Optimum irradiation regimens were shown to be dynamic fractionation of a total dose and the entire period of treatment.