[The physiopathology of acute pancreatitis: the role of platelet-activating factor (PAF)]. / Fisiopatología de la pancreatitis aguda: el papel del factor activador plaquetario (PAF).

PAF-acether (platelet-activating factor) is a vasoactive substance appearing in plasma under certain pathological circumstances. The aim of our study was to determine plasma, peritoneal exudate and tissular levels of PAF-acether in bile reflux acute necro-hemorrhagic pancreatitis (ANP) in the conscious rat 60 minutes after induction. As we have previously demonstrated, ANP causes overwhelming shock in conscious rats. PAF-acether levels increased in plasma and peritoneal exudate of rats with ANP. In contrast, tissular PAF levels were similar to basal values. In conclusion, these data suggest a role of PAF-acether in the hemodynamic impairment that follows induction of pancreatitis.

[Hemodynamic changes in an acute pancreatitis experimental model in awaken rats]. / Alteraciones hemodinámicas en un modelo de pancreatitis aguda experimental en ratas despiertas.

The aim of the present study was to determine the hemodynamic effect of acute hemorrhagic pancreatitis in conscious rats. For this purpose, radioactive microspheres were used in 3 groups: control (n = 5); 25 min pancreatitis (n = 10); 50 min pancreatitis (n = 10), performing a basal and final (25 or 50 minutes postpancreatitis) hemodynamic study. Acute hemorrhagic pancreatitis was induced in 25 min and 50 min pancreatitis groups overwhelming shock with decrease of 55% in cardiac output, 58% in renal blood flow while total peripheral resistance increased in 342%. No changes were registered the in control group.