Acute pernicious beriberi in a patient receiving parenteral nutrition. A case report.

Parenteral nutrition is being used increasingly in the treatment of the critically ill patient but it causes complications and metabolic derangement. A patient receiving parenteral nutrition in whom protracted vomiting from intestinal obstruction led to the development of acute cardiovascular beriberi (Shoshin) with severe metabolic acidosis--probably lactic--is described. The acidosis was refractory to bicarbonate infusion and inotropic support but the administration of intravenous thiamine 100 mg resulted in a dramatic recovery. Biochemical confirmation of thiamine deficiency was obtained by the measurement of an elevated thiamine pyrophosphate level (24.4%). The patient received thiamine 2.4 mg weekly, a dose that proved insufficient. Thiamine deficiency should be considered when patients receiving parenteral nutrition develop metabolic acidosis with a wide anion gap, even if vitamin supplementation appears adequate.

Pancreatic pleural effusion with endoscopic retrograde cholangiopancreatography: A case report.

A case is discussed of a 30-year-old Black woman who developed a massive pseudocyst of the pancreas while under investigation in hospital for a left pleural effusion. An internal pancreatic fistula to the pleural space was demonstrated at endoscopic retrograde cholangiopancreatography. The patient recovered completely after distal pancreatectomy with splenectomy.