[Effect of indirect endolymphatic antibiotic therapy on clinical and immunological indicators in patients with erysipelas of the lower extremities]. / Vliianie nepriamoi éndolimfaticheskoi antibiotikoterapii na klinicheskie i immunologicheskie pokazateli u bol'nykh rozhei nizhnikh konechnostei.

Two groups of patients with erysipelas of the lower extremities underwent indirect endolymphatic therapy with bicillin-3 (58 patients) and routine penicillin therapy (79 patients). Comparative clinicoimmunological examinations in the two groups revealed that lymphotropic administration of the antibiotic had a more favourable effect on the disease process, as evidenced by more rapid reverse time courses of erysipelas clinical signs, less frequent incidence of early relapses and normalization of the majority of immunological parameters by the end of the treatment. For estimation of the anti-recurrence efficacy of the antibiotic therapy in the patients with erysipelas, it was recommended to use a specific scale based on the principles of the Wald successive alternative analysis.

[Changes in the kallikrein-kinin system of patients with erythematous and hemorrhagic forms of erysipelas]. / Izmenenie kallikrein-kininovoi sistemy u bol'nykh s éritematoznoi i gemorragicheskoi formoi rozhi.

The state of the kallikrein-kinin system of the blood (KKS): kallikrein (KK), prekallikrein (PK), general arginine-esterase activity (GAEA), alpha 1 inhibitor of protease (IP) and alpha 2-macroglobulin (MG). The initial period of the disease was characterized by an increase of the level of KK, GAEA, IP and MG and a reduction of PK. It was established that the maximal activation of KKS develops in patients with the erythematous form of erysipelas during the first days of the disease, with the hemorrhagic form--on the 2 week. During convalescence KKS indices showed the reverse dynamics but did not reach normal levels in most patients. It is suggested that there is a relationship of the "rapid" form of KKS activation with formation of erythematous erysipelas, the "slow"--with hemorrhagic erysipelas. It is recommended to use the KKS indices, primarily KK activity for prediction of hemorrhagic erysipelas at the early prehemorrhagic stage.

[The use of the kallikrein-kininogen system indices in the prognosis of the development of hemorrhagic erysipelas]. / Ispol'zovanie pokazatelei kallikrein-kininovoi sistemy dlia prognoza razvitiia gemorragicheskoi formy rozhi.

A number of the kallikrein-kinin system parameters (kallikrein, prekallikrein, total arginine esterase activity, alpha 1 protease inhibitor, and alpha 2 macroglobulin) were measured in 59 patients with erythematous erysipelas and in 51 ones with hemorrhagic erysipelas over the course of the disease. Marked activation of the blood kallikrein-kinin system was seen in all the patients during the initial period of the disease, manifesting by elevated levels of kallikrein, total arginine esterase activity, alpha 1 protease inhibitor, alpha 2 macroglobulin, and a lowered prekallikrein concentration. In erythematous erysipelas the peak of activation was recorded in the first days of the disease, whereas in hemorrhagic condition it was observed during the second week of erysipelatous inflammation. Different patterns of changes in the kallikrein-kinin system over the course of the disease permit using one of its parameters, kallikrein activity, for the prediction of the development of local hemorrhagic syndrome in erysipelas patients already during the earliest (prehemorrhagic) stage of the condition.