[Phospholipid composition of erythrocytes in patients with chronic kidney failure]. / Fosfolipidnyi sostav éritrotsitov u bol'nykh khronicheskoi pochechnoi nedostatochnost'iu.

Qualitative and quantitative composition of lipid fractions was studied in erythrocytes of 221 patients (16-62 years old) in the terminal step of chronic renal failure. The following lipid fractions were studied: total phospholipids, monoglycerides, cholesterol, free fatty acids, diglycerides, triglycerides, methyl esters of fatty acids, cholesterol esters, lysophosphatidyl choline, phosphatidyl serine, lysophosphatidyl ethanolamine, sphingomyelin, phosphatidyl inositol, phosphatidyl choline, lysocardiolipin, phosphatidyl ethanolamine, cardiolipin, lysophosphatidic acid and phosphatidic acid. The alterations observed in the phospholipid composition of erythrocyte membranes appear to occur due to intracellular transformations related to specific metabolism in uremia. These alterations of phospholipid composition in erythrocyte membranes of patients with chronic renal failure, which were found to be intoxication-dependent, may be used in prognostic evaluation of patients' state under conditions of uremia development.

[The problems of viral hepatitis B in hemodialysis units]. / Problemy virusnogo gepatita B v otdeleniiakh gemodializa.

To study the spread of viral hepatitis B in hemodialysis departments, 92 patients and 52 members of the personnel were examined at such department. The presence of the complex of viral hepatitis B markers was determined with the use of such highly sensitive techniques as the radioimmunoassay and the enzyme immunoassay. All markers of hepatitis B virus infection were detected altogether in 50% of the patients and 79.1% of the personnel of the department. Clinico-laboratory studies revealed a considerable proportion of persons with chronic forms of the disease among these subjects. In patients with chronic renal insufficiency the latent course of the disease was mainly established, which probably ensured the continuity of the epidemic process at the department. Taking into account the present epidemiological situation, the main measures for the prophylaxis of viral hepatitis B at hemodialysis departments were recommended. The conclusions made on the basis of these studies emphasize that a wide complex of anti-epidemic measures for controlling viral hepatitis B was necessary at hemodialysis departments.