RESUMO
BACKGROUND: The present study aims to determine the predictive power of activin A levels in the prognosis of first trimester pregnancies conceived by in vitro fertilization (IVF). METHODS: The study cohort included 23 biochemical, and 23 normal ongoing pregnancies conceived via IVF. Serum ß-human chorionic gonadotropin (ß-hCG), progesterone, and activin A levels were assessed 14 days after embryo transfer. RESULTS: Serum activin A levels were significantly lower in biochemical pregnancies compared to normal ongoing pregnancies (0.57 vs. 0.81 ng/mL, p<0.001). The ability of activin A to predict normal ongoing pregnancies at a cutoff level of 0.695 ng/mL gave a sensitivity of 91.3%, a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 92%. Significant correlation was found between ß-hCG and progesterone, ß-hCG and activin A, and progesterone and activin A. Activin A, ß-hCG, and progesterone were all found to be efficacious in prediction of early IVF pregnancies. CONCLUSIONS: The present study indicates that single measurement of activin A can be suggested as a marker for the progress and outcome of early pregnancies conceived via IVF. However, further large-scale studies are required to determine the efficacy and reliability of activin A in prediction of early pregnancies achieved by assisted reproductive techniques (ART).
Assuntos
Ativinas/sangue , Biomarcadores/sangue , Fertilização in vitro , Testes de Gravidez/métodos , Primeiro Trimestre da Gravidez/sangue , Adulto , Gonadotropina Coriônica Humana Subunidade beta/sangue , Estudos de Coortes , Feminino , Humanos , Gravidez , Testes de Gravidez/normas , Progesterona/sangue , Prognóstico , Curva ROC , Sensibilidade e Especificidade , Ultrassonografia/métodos , Adulto JovemRESUMO
Primary ovarian ectopic pregnancy occurs quite rarely. Primary ovarian ectopic pregnancies usually occur in young, highly fertile, multiparous women using IUD. Two cases, we presented were middle aged, infertility and did not use IUD. The treatment of choice for ovarian pregnancy is usually ovarian wedge resection or oophorectomy, also there is a place for medical treatment of carefully selected patients. In this report, we aimed to present the laparoscopic conservative treatment of spontaneous ovarian ectopic pregnancy in two patients who had primary infertility.
