RESUMO
1. In the present study, the pressor and antinociceptive effects of physostigmine and oxotremorine were investigated in rats injected with AF64A intracerebroventricularly. 2. Physostigmine (50-100 micrograms/kg, i.v.)-induced pressor responses were significantly lower in AF64A-injected rats compared with saline-injected animals, whereas oxotremorine (20-80 micrograms/kg, i.v.)-induced responses were found to be similar to those seen in the saline group. 3. The physostigmine (100 micrograms/kg, s.c.)-induced antinociceptive effect was totally abolished by AF64A treatment, but that of oxotremorine (30 micrograms/kg, s.c.) remained unchanged at the tail-flick test. 4. The results of this study present functional evidence for AF64A-produced substantial loss of cholinergic neurons involved in the regulation of blood pressure and nociception but not in postsynaptic muscarinic receptors.
Assuntos
Aprendizagem da Esquiva/efeitos dos fármacos , Aziridinas/farmacologia , Colina/análogos & derivados , Aprendizagem em Labirinto/efeitos dos fármacos , Bloqueadores Neuromusculares/farmacologia , Analgesia , Animais , Colina/farmacologia , Inibidores da Colinesterase/farmacologia , Feminino , Masculino , Agonistas Muscarínicos/farmacologia , Oxotremorina/farmacologia , Medição da Dor , Fisostigmina/farmacologia , Ratos , Ratos Sprague-DawleyRESUMO
A clear perception of the psychologic factors affecting both the physician and the patient can greatly influence the course of therapy in diabetes. Genuine, realistic assessment and acceptance of the limitations inherent in physician-patient interactions will lead to considerably more satisfying personal and professional relationships.
