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1.
Gan To Kagaku Ryoho ; 50(1): 81-83, 2023 Jan.
Artigo em Japonês | MEDLINE | ID: mdl-36759993

RESUMO

Desmoid tumor is a rare tumor of the soft tissue. The frequency of occurrence is 2.4 to 4.3 cases per year per million people, which is a very rare disease. We experienced a huge intra-abdominal desmoid tumor which is thought to be the primary mesentery. The case was a male in his 20s. He visited a nearby doctor with a complaint of abdominal bloating and abdominal pain. Abdominal contrast CT revealed a huge abdominal mass with a clear boundary of 35×25 cm in size extending from the upper right abdomen to the pelvis. Surgery was performed with a diagnosis of an intra-abdominal mass. Open abdominal tumor resection. Due to infiltration into the duodenum, transverse colon, and pancreas, right hemicolectomy and duodenal combined resection were performed. The pathological diagnosis was a diagnosis of desmoid tumor.


Assuntos
Fibromatose Abdominal , Fibromatose Agressiva , Humanos , Masculino , Fibromatose Agressiva/cirurgia , Fibromatose Agressiva/diagnóstico , Fibromatose Abdominal/cirurgia , Fibromatose Abdominal/diagnóstico , Mesentério/patologia , Duodeno/patologia , Pâncreas/patologia
2.
Gan To Kagaku Ryoho ; 50(13): 1537-1539, 2023 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-38303333

RESUMO

A man in his 80s was referred to our hospital for further examination of partial pancreatic atrophy that was detected incidentally. Various imaging examinations including CT, MRI, and EUS did not reveal any obvious abnormal findings other than the partial pancreatic atrophy. However, cytological examination of serial pancreatic juice aspiration showed atypical cells. The presence of pancreatic intraepithelial carcinoma in the atrophy site was considered, and the patient underwent laparoscopic distal pancreatectomy. Pathological examination of the excised specimen confirmed the presence of high-grade pancreatic intraepithelial neoplasia consistent with the atrophy site, and the patient was diagnosed with pTisN0M0, Stage 0 pancreatic cancer. For the detection of early pancreatic cancer, it is important to be aware of partial pancreatic atrophy on imaging studies.


Assuntos
Carcinoma in Situ , Neoplasias Pancreáticas , Humanos , Masculino , Atrofia/patologia , Carcinoma in Situ/cirurgia , Pâncreas/patologia , Pancreatectomia , Suco Pancreático , Neoplasias Pancreáticas/patologia , Idoso de 80 Anos ou mais
3.
Gan To Kagaku Ryoho ; 49(13): 1774-1776, 2022 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-36732995

RESUMO

A 74-year-old man with no chronic liver disease was admitted for an incidental liver tumor by computed tomography. Serological examinations for hepatitis B and C virus were negative and tumor markers, including carcinoembryonic antigen, α-fetoprotein, carbohydrate antigen 19-9, and des-gamma-carboxy prothrombin, were within the normal range. The contrast- enhanced magnetic resonance imaging revealed that the 26 mm in diameter patchy tumor occupied the S7 in the liver. The tumor boundary was enhanced slightly in the arterial phase and inside gradually in the portal phase, and the enhancement was faded in the late phase. As a characteristic finding, vessels penetrated the tumor. The tumor was diagnosed as cholangiocarcinoma, and the patient underwent right lateral sectionectomy. After 19 days postoperatively, the patient was discharged. The diagnosis of hepatic mucosa-associated lymphoid tissue(MALT)lymphoma was made by pathological examination. Currently, the patient has no recurrence for 5 months without adjuvant chemotherapy. The primary hepatic MALT lymphoma is a rare disease among primary hepatic malignant lymphomas. The patient must be followed up carefully because 2 cases were reported as recurrent cases after several years postoperatively although the disease has a good prognosis.


Assuntos
Neoplasias dos Ductos Biliares , Neoplasias Hepáticas , Linfoma de Zona Marginal Tipo Células B , Masculino , Humanos , Idoso , Linfoma de Zona Marginal Tipo Células B/tratamento farmacológico , Linfoma de Zona Marginal Tipo Células B/cirurgia , Neoplasias Hepáticas/patologia , Neoplasias dos Ductos Biliares/complicações , Ductos Biliares Intra-Hepáticos/patologia
4.
Gan To Kagaku Ryoho ; 49(13): 1799-1801, 2022 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-36733003

RESUMO

The patient is a 52-year-old woman who visited the general practitioner because of positive fecal occult blood test by medical examination. The patient underwent colonoscopy at the hospital, which revealed sigmoid colon cancer. Therefore, the patient was referred to our hospital for surgery. Preoperative CT scan revealed a well-defined and lobulated 54 mm tumor on the caudal side of the duodenal third portion. On MRI, the tumor showed low T1-weighted image signal and high T2-weighted and diffusion-weighted images signal, with low ADC. For preoperative diagnosis, we diagnosed sigmoid colon cancer and transverse colon mesenteric and performed laparoscopic sigmoid colon and transverse colon mesenteric tumor resections. The histopathological tumor diagnoses were sigmoid colon cancer(S, type 2, 30×30 mm, 1/2 circumference, moderately differentiated adenocarcinoma, pT3[SS], INF b, Ly1a, V1a, pN1b[#252: 2/4], sM0, fStage Ⅲb)and transverse colon mesentery primary solitary fibrous tumor. The patient was treated with XELOX as the adjuvant chemotherapy and survived without recurrence until present.


Assuntos
Colo Transverso , Neoplasias do Colo Sigmoide , Tumores Fibrosos Solitários , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias do Colo Sigmoide/tratamento farmacológico , Neoplasias do Colo Sigmoide/cirurgia , Neoplasias do Colo Sigmoide/patologia , Colo Transverso/cirurgia , Colo Transverso/patologia , Colo Sigmoide/patologia , Colo Sigmoide/cirurgia , Mesentério/cirurgia , Mesentério/patologia , Tumores Fibrosos Solitários/cirurgia
5.
Gan To Kagaku Ryoho ; 49(13): 1826-1828, 2022 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-36733012

RESUMO

A 43-year-old woman with about abdominal distension was referred to our hospital for a more detailed examination. Abdominal CT showed 27 cm-sized cystic lesion with the calcification along the partition wall and a nodular hyperplasia. We suspected pancreatic pseudocyst, primary retroperitoneal tumor and we performed tumorectomy. The resected specimen had a maximum diameter of 27 cm. The histopathological diagnosis was mucinous cystadenocarcinoma of the pancreas with ovarian-type stroma. The adjuvant chemotherapy treated with gemcitabine was selected for 3 courses. She continues to do well without any recurrences 7 months later.


Assuntos
Cistadenocarcinoma Mucinoso , Neoplasias Pancreáticas , Neoplasias Retroperitoneais , Feminino , Humanos , Adulto , Neoplasias Pancreáticas/tratamento farmacológico , Neoplasias Pancreáticas/cirurgia , Neoplasias Pancreáticas/diagnóstico , Pâncreas/patologia , Cistadenocarcinoma Mucinoso/tratamento farmacológico , Cistadenocarcinoma Mucinoso/cirurgia , Cistadenocarcinoma Mucinoso/diagnóstico , Gencitabina
6.
Ann Vasc Surg ; 22(3): 476-80, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18466824

RESUMO

Infected aneurysms due to Campylobacter fetus subspecies fetus have rarely been reported. Here, we describe the first case of infected aneurysm of bilateral deep femoral arteries due to C. fetus fetus. We successfully treated this case by administration of antibiotics effective for C. fetus fetus and bilateral obturator bypass with complete resection of the infected aneurysms. The aneurysmal wall culture disclosed the presence of C. fetus fetus in a microaerobic atmosphere after the operation. A distinctive culture condition was necessary to detect C. fetus fetus. In the case of infected aneurysms, we should be aware of the possibility of infection with C. fetus fetus, and an appropriate culture for this organism may be needed.


Assuntos
Aneurisma Infectado/microbiologia , Infecções por Campylobacter/microbiologia , Campylobacter fetus/isolamento & purificação , Artéria Femoral/microbiologia , Idoso , Aneurisma Infectado/diagnóstico por imagem , Aneurisma Infectado/terapia , Antibacterianos/uso terapêutico , Implante de Prótese Vascular , Infecções por Campylobacter/diagnóstico por imagem , Infecções por Campylobacter/terapia , Campylobacter fetus/classificação , Artéria Femoral/diagnóstico por imagem , Artéria Femoral/cirurgia , Humanos , Masculino , Tomografia Computadorizada por Raios X , Resultado do Tratamento
7.
Nat Med ; 11(12): 1330-8, 2005 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16311603

RESUMO

Abdominal aortic aneurysm (AAA) is a common disease among elderly people that, when surgical treatment is inapplicable, results in progressive expansion and rupture of the aorta with high mortality. Although nonsurgical treatment for AAA is much awaited, few options are available because its molecular pathogenesis remains elusive. Here, we identify JNK as a proximal signaling molecule in the pathogenesis of AAA. Human AAA tissue showed a high level of phosphorylated JNK. We show that JNK programs a gene expression pattern in different cell types that cooperatively enhances the degradation of the extracellular matrix while suppressing biosynthetic enzymes of the extracellular matrix. Selective inhibition of JNK in vivo not only prevented the development of AAA but also caused regression of established AAA in two mouse models. Thus, JNK promotes abnormal extracellular matrix metabolism in the tissue of AAA and may represent a therapeutic target.


Assuntos
Antracenos/farmacologia , Aneurisma da Aorta Abdominal/tratamento farmacológico , Aneurisma da Aorta Abdominal/prevenção & controle , Matriz Extracelular/metabolismo , Regulação da Expressão Gênica/genética , Proteínas Quinases JNK Ativadas por Mitógeno/antagonistas & inibidores , Adenoviridae , Animais , Aorta/química , Western Blotting , Células Cultivadas , Ensaio de Imunoadsorção Enzimática , Proteínas da Matriz Extracelular/biossíntese , Vetores Genéticos , Humanos , Metaloproteinase 9 da Matriz/metabolismo , Camundongos , Análise em Microsséries , Extratos de Tecidos/metabolismo
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