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Artigo em Inglês | MEDLINE | ID: mdl-31421737

RESUMO

Welding technology is widely used in pressurized containers, thermal power plants, refineries, chemical facilities and steel structures. Welders are exposed to a number of hazardous compounds such as ultraviolet (UV) radiation, electromagnetic fields, toxic metals and polycyclic aromatic hydrocarbons (PAHs). In the present study, 48 welders and an equal number of control subjects were evaluated for DNA damage in the whole blood and isolated lymphocytes using the comet assay. The genotoxic damage in buccal epithelial cells of subjects was determined by micronucleus (MN) assay. Metal(loids) such as Cr, Mn, Ni, Cu, As, Cd and Pb levels in blood samples were evaluated by using Inductively Coupled Plasma-Mass Spectrometer (ICP-MS). Results of this study showed that DNA damage in blood, isolated lymphocytes, and buccal epithelial cells were significantly higher in workers compared to the controls. Also, these workers had remarkably higher blood Cr, Cu, Cd, Ni and Pb levels. These results showed that occupational exposure to welding fumes may cause genotoxic damage that can lead to important health problems in the workers. More extensive epidemiological studies should be performed that enable the assessment of health risk in welding industry.


Assuntos
Poluentes Ocupacionais do Ar/toxicidade , Ensaio Cometa , Dano ao DNA , Testes para Micronúcleos , Exposição Ocupacional , Soldagem , Adolescente , Adulto , Consumo de Bebidas Alcoólicas/epidemiologia , Consumo de Bebidas Alcoólicas/genética , Fumar Cigarros/epidemiologia , Fumar Cigarros/genética , Células Epiteliais/química , Células Epiteliais/efeitos dos fármacos , Células Epiteliais/ultraestrutura , Humanos , Linfócitos/química , Masculino , Espectrometria de Massas/métodos , Metais Pesados/sangue , Metais Pesados/toxicidade , Pessoa de Meia-Idade , Mucosa Bucal/citologia , Equipamento de Proteção Individual , Análise de Célula Única , Adulto Jovem
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