[Features of adaptation of newborns born to mothers with endemic goiter]. / Osobennosti adaptatsii novorozhdennykh, rodivshikhsia u materei s éndemicheskim zobom.

Relationships between chronic iodine deficiency and, among other things, endemic goiter in women and adaptation of their babies in the early neonatal period were studied. A total of 125 women with endemic goiter of the Ist-IInd degrees and their newborns were examined. The diagnosis of endemic goiter was verified by the findings of an objective examination, ultrasonic examination, and puncture biopsy of the thyroid. Blood levels of triiodothyronine and thyroxin were measured in the women on days 3-4 postpartum. In the newborns Apgar score, body mass and length at birth, degree of maturity, physiologic body mass loss, duration of the icteric syndrome, time of umbilical cord drop off, and immunity status from the data of NBT test were assessed. Forty-five women without goiter and their newborns were controls. Postpartum measurements of triiodothyronine and thyroxin levels in the blood of patients with endemic goiter brought the authors to a conclusion that subclinical hypothyrosis was characteristic of them. Adaptation processes in the early neonatal period were found disordered in the newborns of mothers with endemic goiter. This manifested by a higher, vs. controls, incidence of asphyxia, hypotrophy, signs of the CNS involvement, and respiratory distress syndrome. Initial body mass recovery, disappearance of the icteric syndrome, umbilical cord loss were delayed in these newborns in comparison with the controls, and statistically reliable deviations in their immune status were revealed.

[Means of improving the chemoradiotherapy of small cell cancer of the lung]. / Puti sovershenstvovaniia khimioluchevoi terapii melkokletochnogo raka legkogo.

The report deals with an analysis of the results of treatment of 84 patients suffering small cell lung cancer. Four regimens of combination chemotherapy as well as radiation were used. Complete plus partial regression rates ranged 18-81% (mean-42%) following chemotherapy and 73-87% after radiation treatment. Platidiam-containing schemes proved most effective. Prophylactic cranial irradiation was followed by increased survival. A correlation between extent of tumor and effectiveness of treatment was established.

[Clinico-pharmacological study of prospidin]. / Kliniko-farmakologicheskoe izuchenie prospidina.

Different schemes of prospidin administration to 54 patients were evaluated. Stage IV paresthesia or renal derangements are limitations of prospidin treatment due to its toxicity. Rheovasographic studies established that disorders in vascular tension are responsible for paresthesia development. The best results were obtained with the administration of 300-400 mg every other day for 2-3 weeks. Schemes of combined administration of prospidin and cyclophosphamide and bleomycin were worked out (58 cases). Therapeutic effect was recorded in the treatment of melanoma, carcinoma of the lip, tongue, nasopharynx, salivary gland and skin. Prospidin, cyclophosphamide and radiation therapy were successfully used in the management of small cell carcinoma of the lung.