1.
Bioorg Med Chem Lett
; 26(24): 5877-5882, 2016 12 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27864071
RESUMO
The syntheses, structure-activity relationships (SARs), and biological activities of tetrahydroquinoline-based tricyclic amines as 5-HT2C receptor agonists are reported. An early lead containing a highly unique 6,6,7-ring system was optimized for both in vitro potency and selectivity at the related 5-HT2B receptor. Orally bioactive, potent, and selective 6,6,6-tricyclic 5-HT2C agonists were identified.