Long-term spatiotemporal analysis of the climate related impact on the transmission rate of COVID-19.

BACKGROUND: The association between weather conditions and the spread of COVID-19 was demonstrated by previous studies but focused on specific countries or investigated shorter periods of duration limiting the interpretation of the results. AIM: To make an international comprehensive insight into the association between the weather conditions and the spread of COVID-19 by spanning many regions in the Northern and Southern hemispheres over a period of two years for the COVID-19 Outbreak. METHODS: The data were analyzed by using statistical description, linear and multiple regressions, and the Spearman rank correlation test. Daily and weekly COVID-19 cases, the average temperatures, Wind Speed, the amount of precipitation as well as the relative humidity rates were collected from Irbid, Jordan as the main location of analyses, as well as comparison cities and countries in both hemispheres. RESULTS: we found that certain climate variables are significant factors in determining the transmission rate of COVID-19 worldwide. Where, The temperature in the northern hemisphere regions was the most important climate factor that affects the increase in the transmission rate of COVID-19 (Northern Hemisphere rs = -0.65; Irbid rs = -0.74995; P < 0.001), While in southern hemisphere, the climate factor that affects the increase in the transmission rate of COVID-19 was the humidity (rs = 0.55; P < 0.01), In addition, we found the negligible and oscillated effect of wind speed on the transmission rate of COVID-19 worldwide. Moreover, we found that in Irbid 82% of COVID-19 cases were in the fall and winter seasons, while in summer the percentage of COVID-19 cases didn't exceed 3% during the total study period. CONCLUSION: This study can help develop international strategies and policies against COVID-19-related pandemic peaks, especially during the colder seasons in the Northern Hemisphere regions from the first month of fall to the last month of winter.

Familial Mediterranean fever mutation frequencies and carrier rates among a mixed Arabic population.

OBJECTIVE: Familial Mediterranean Fever (FMF) is an autoinflammatory periodic disorder characterized by febrile and painful attacks due to inflammation involving the serosal membranes. The gene implicated in this disorder, MEFV, has been cloned and mutations in its coding regions have been identified. We aimed at identifying the frequency of MEFV mutations and carrier frequency in a mixed Arabic population. METHODS: We identified 29 probands from 29 unrelated sibships segregating the disorder and representing the affected individual cohort. We screened 200 anonymous deoxyribonucleic acid (DNA) samples, representing a healthy adult cohort, for the mutations found to be common in the affected individual cohort. We also, screened anonymous DNA samples from 4 Arabic countries, namely, Egypt (231), Syria (225), Iraq (176) and the Kingdom of Saudi Arabia (107) thus enlarging our healthy adult cohort. The study was carried out between 1999 and 2002 at Jordan University of Science and Technology, Irbid and the University of Jordan, Amman, Jordan. RESULTS: Out of the 58 alleles of the 29 probands, only 31 mutations were identified and M694V and V726A are the most common. The mutation E148Q was the most common among the healthy adult cohort, but was not present in affected individuals. The collective mutant allele frequency "q" was 0.101. The expected carrier rate was 18.1% (one in 5.5) while the observed carrier rate was 18.4% (one in 5.4). CONCLUSION: E148Q has reduced penetrance and thus, a proportion of the individuals genetically affected with FMF remain asymptomatic. M694I and M680I are more prevalent in the affected individuals cohort, which points to their higher penetrance. The overall carrier rate is one in 5, but the selective heterozygote advantage could not be demonstrated in this study due to the relatively small sample size.

Epidemiology and management of hypertension among Bedouins in Northern Jordan.

OBJECTIVE: To estimate the magnitude of hypertension, and its levels of awareness and control of hypertension among a community of Jordanian aborigines in Northern Jordan; and to compare the study findings with findings from other Jordanian communities. METHODS: A systematic sample of 50% of all households of Qafqafa, Northern Jordan was selected and all members of the selected households were included in the study at Qafqafa Health Center, Qafqafa, Jordan. A structured questionnaire was administered to all study participants and measurement of blood pressure was performed according to a preset criteria. Data on 366 subjects included in the sample were collected during the months of April and May 2002. RESULTS: A total of 40 subjects or 10.9% were suffering from hypertension. Prevalence rate of hypertension was significantly lower than the 16.1% and 16.3% prevalence rates reported from other more modernized Jordanian communities. Logistic regression analysis indicated that hypertension was positively associated with masculinity, age, illiteracy, obesity, and with positive family history of hypertension. No association was detected between hypertension and each of smoking, Diabetes mellitus, and total serum cholesterol. This study showed that one-half (47.5%) of hypertensives were unaware of their diagnosis and more than one-half (57.1%) of those aware of their diagnosis did not achieve control of their hypertension. CONCLUSION: Population of the study community has significantly lower levels of hypertension than both semi-urban and recently urbanized Jordanian communities, and much of the rise in blood pressure levels is attributed to environmental factors. Moreover, hypertension management programs in Jordan are far below the optimal standards.

Genotype/phenotype correlations in Arab patients with familial Mediterranean fever.

OBJECTIVES: To study the phenotype/genotype correlations in Arab patients with familial Mediterranean fever (FMF). PATIENTS AND METHODS: The study was performed in a 3-year period (February 1998-February 2001). Patients were seen in the pediatric FMF clinic of Jordan University Hospital, and the diagnosis of FMF was made according to published criteria. Screening for mutations was carried out by direct sequencing of the entire coding sequence of exon 10 and its donor splice site and by restriction endonuclease testing for mutations in exon 2. A total of 278 patients with clinically positive FMF were screened. RESULTS: Of the 278 patients, 50 (18%) had 2 mutations identified, and 76 (27%) other patients had only 1 mutation identified. The 50 patients with 2 mutations are the subject of this report. The M694V/M694V and the M694V/V726A and M694I/M694I genotypes were the most common (30%, 16%, and 14%, respectively). Three homozygous genotypes (M694V/M694V, V726A/V726A, and M694I/M694I) and 2 compound heterozygous genotypes (M694V/V726A and V726A/M680I) accounted for 78% of mutations. The difference in the mean severity score (14 +/- 2) of the M694V/M694V group and the V726A/V726A (mean severity score, 10 +/- 3) and M694I/M6941 (mean severity score, 6 +/- 1) groups was statistically significant (P =.003 and.0, respectively). The difference between the M649V/M694V group and the M694V/V726A (mean severity score, 15 +/- 2) was not statistically significant (P = 0.31). CONCLUSIONS: The genotypes M694V/M694V and M694V/V726A have a severe clinical course in Arab patients with FMF, whereas the M694I/M694I is associated with mild disease.