RESUMO
This investigation was undertaken to study the immune response of Iraqi sheep vaccinated with Dictyocaulus filaria larvae (Filiraq) and to determine the effect of tetramisole on the development of resistance to reinfection. The findings confirm the effectiveness of Filiraq in conferring protection against experimental infection with D filaria. However, the administration of anthelmintic four weeks after each vaccination interfered with the development of immunity. Termination of D filaria infection at 28 days by tetramisole treatment also prevented the immune response.
Assuntos
Infecções por Dictyocaulus/imunologia , Dictyocaulus/imunologia , Metastrongyloidea/imunologia , Doenças dos Ovinos/imunologia , Tetramizol/farmacologia , Vacinas/imunologia , Animais , Peso Corporal , Terapia Combinada , Infecções por Dictyocaulus/tratamento farmacológico , Imunidade/efeitos dos fármacos , Masculino , Ovinos , Doenças dos Ovinos/tratamento farmacológico , Tetramizol/uso terapêutico , Vacinas Atenuadas/imunologiaRESUMO
Sulphadiazine, sulphatiazole and sulphamerazine were shown to be excreted through the ruminal wall and salivary glands of cows. These sulphonamides had a slight inhibitory effect on cellulose digestion and on the activity of rumen infusoria. Acetylation of the sulphonamides occurred to a slight extent. Sulphatiazole was more acetylated (16.2 per cent) than sulphadiazine (7.0 per cent) or sulphamerazine (8.4 per cent). The rate of elimination of the three compounds, as indicated by their half lives, showed that sulphathiazole was the most rapidly excreted (2 h), whereas sulphadiazine and sulphamerazine were more slowly excreted, 5.4 and 7.1 h respectively.
