A clinicopathological study of women with adnexal masses presenting with acute symptoms.

BACKGROUND: Abdominal pain is one of the most common presentations of adnexal pathology in gynecology. Early diagnosis and intervention is essential especially in adolescent girls and reproductive age group women to conserve reproductive function. AIM: The purpose of the following study is to assess the clinicopathologic outcome of women with adnexal masses presenting with acute pain. SUBJECTS AND METHODS: A retrospective study of women with adnexal masses who had surgical intervention for acute symptoms from June 2007 to May 2012 was undertaken. During the study period, a total of 57 women were operated for adnexal masses as emergency. RESULTS: Of the 57 women operated for adnexal masses as emergency, the most common pathology was teratoma 26% (15/57) followed by corpus luteal hemorrhage (16%) and endometriosis (14%). Laparoscopy was the initial surgical approach in just over 50% of patients, but surgery was completed laparoscopically only in about one-third of patients. Conservative surgery in the form of ovarian cystectomy was possible in 70% of patients. CONCLUSION: Complications of adnexal masses such as torsion and hemorrhage are common causes of acute abdominal pain. Timely diagnosis of the adnexal pathology and surgical intervention will help to preserve the reproductive outcome. Conservative surgery was possible in 70% of our study group.

Utilization of fentanyl buccal tablets in England: exploring off-label use reported in a cohort study.

BACKGROUND: Fentanyl citrate buccal tablets are indicated for the treatment of breakthrough pain (BTP) in cancer, in adults who are receiving maintenance opioid therapy for chronic cancer pain. OBJECTIVE: One of the objectives of this study was to describe the utilization characteristics of patients prescribed fentanyl buccal and to assess how the product is being used in relation to the terms of license of marketing approval. METHODS: An observational post-marketing cohort study was conducted. For the analysis of this study, exposure data were collected from dispensed prescriptions issued by general practitioners (GPs) between March 2009 and June 2011. Outcome data (indication, event, patient demographic and selected clinical characteristics) were collected by sending questionnaires to GPs at least 6 months after the drug was first prescribed. Summary descriptive statistics were calculated. RESULTS: The cohort consisted of 551 patients, of which 54.8% (n = 302 patients) were female. The median age for the cohort was 62 years (interquartile range: 50-72 years), with one patient (0.2%) aged less than 18 years. A primary indication of BTP in cancer was reported for 61.9% (n = 341) patients. Regular opioid therapy was reported upon starting the treatment for 383 patients (69.5% of cohort). In total, 69 patients (12.5%) had one or more contraindications for use. The most frequent initial titration dose was 100 µg/day (n = 247). CONCLUSIONS: The final study results show that fentanyl buccal is largely being prescribed according to the terms of the license in general practice in England, but off-licence use and use in the presence of contraindications and warnings have been reported.

Serum sodium changes during and after transuretheral prostatectomy.

OBJECTIVE: This prospective study aims at determining the effect of transurethral resection of the prostate on serum sodium levels during and after the procedure. METHODS: One hundred consecutive unselected patients with prostatic obstructive symptoms over a period of 11 months underwent transurethral resection of the prostate using continuous flow irrigation with 1.5% glycine running from a height of 70 cm above the table level under epidural anesthesia and were given 1L of intravenous normal saline/hour during the procedure. Resection time ranged between 25 and 90 minutes (mean 32) and was less than 45 minutes in 91 patients (91%). No postoperative irrigation or diuretics were given and the patients were given food and liberal fluids immediately after the operation. RESULTS: Fifty-four patients (54%) had intraoperative reduction of serum sodium ranging between 2 and 7 mmol/L (mean 3.5), 18 of whom showed further drop of 2-10 mmol/L after 24 hours (mean 3.4). Twenty-five patients (25%) did not have any intraoperative change in their serum sodium level, 6 of whom dropped their serum sodium 24 hours later. After 24 hours, 41 patients (41%) ended with serum sodium lower than their preoperative level by 2-12 mmol/L (mean 4%), 3 of whom had a drop of 10-12 mmol/L. The reduction was manifested 24 hours after the procedure in 27 patients (27%). None of the patients had transurethral resection syndrome nor its prodromal manifestations. CONCLUSION: After transurethral resection of the prostate, hyponatremia can occur as late as 24 hours postoperatively. Short operative time, giving intravenous sodium supplement intraoperatively and avoiding postoperative irrigation were perhaps factors in avoiding drastic hyponatremia and transurethral resection syndrome in this prospective series of unselected patients.