RESUMO
Neonatal septicaemia is a major cause of morbidity and mortality in developing countries. We studied 118 neonates admitted to the main referral hospital in Al-Anbar with positive blood cultures. The incidence of neonatal septicaemia for babies born at this hospital was 9.2 per 1000 live births, and mortality was 28%. Staphylococcus aureus (39%), Klebsiella pneumoniae (30%) and Escherichia coli (21%) constituted 90% of all isolates. The isolates showed in vitro susceptibility to cefotaxime, chloramphenicol and gentamicin, but resistance to more commonly used antibiotics such as ampicillin and cloxacillin. We recommend initial gentamicin/cefotaxime combined therapy while awaiting culture and sensitivity test results. Our study highlights the importance of understanding the local epidemiology of neonatal septicaemia in formulating a rational antibiotics policy.
Assuntos
Bacteriemia/congênito , Bacteriemia/epidemiologia , Unidades de Terapia Intensiva Neonatal , Bacteriemia/tratamento farmacológico , Bacteriemia/microbiologia , Cefotaxima/uso terapêutico , Farmacorresistência Bacteriana , Quimioterapia Combinada/uso terapêutico , Infecções por Escherichia coli/congênito , Infecções por Escherichia coli/epidemiologia , Feminino , Gentamicinas/uso terapêutico , Mortalidade Hospitalar , Humanos , Incidência , Mortalidade Infantil , Recém-Nascido , Iraque/epidemiologia , Infecções por Klebsiella/congênito , Infecções por Klebsiella/epidemiologia , Klebsiella pneumoniae , Masculino , Testes de Sensibilidade Microbiana , Morbidade , Vigilância da População , Estudos Prospectivos , Encaminhamento e Consulta , Fatores de Risco , Infecções Estafilocócicas/congênito , Infecções Estafilocócicas/epidemiologia , Staphylococcus aureusRESUMO
Neonatal septicaemia is a major cause of morbidity and mortality in developing countries. We studied 118 neonates admitted to the main referral hospital in Al-Anbar with positive blood cultures. The incidence of neonatal septicaemia for babies born at this hospital was 9.2 per 1000 live births, and mortality was 28%. Staphylococcus aureus [39%], Klebsiella pneumoniae [30%] and Escherichia coli [21%] constituted 90% of all isolates. The isolates showed in vitro susceptibility to cefotaxime, chloramphenicol and gentamicin, but resistance to more commonly used antibiotics such as ampicillin and cloxacillin. We recommend initial gentamicin/cefotaxime combined therapy while awaiting culture and sensitivity test results. Our study highlights the importance of understanding the local epidemiology of neonatal septicaemia in formulating a rational antibiotics policy
