[Treatment of recurrent aphthous stomatitis with application of a preparation of a hesperidin 5.0%].

Open randomized 2-year trial has been performed to analyze effectiveness of Unguentum of a hesperidin developed by us for the treatment of recurrent aphthous stomatitis. 80 patients with recurrent aphthous stomatitis in the age from 15 till 60 years from the contingent of the polyclinic of the veterans of Tbilisi were studied. After inclusion of the preparation into the treatment the pain and duration of inflammatory process have been decreased; the complications were not observed. In the group of patients getting treatment with hesperidin, frequency of unsatisfactory outcomes decreased significantly (chi(2)=9,8, p < 0,05). Reduction of relative risk of unsatisfactory outcomes was about 0,8 (95% CI: 0,29-0,86), reduction of absolute risk - 0,33 (95% CI: 0,13-0,52). It may be concluded that application of a preparation may be considered as one of the options for the treatment of recurrent aphthous stomatitis.

[Association of the ABO blood group system and hip joint dysplasia]. / Assotsiatsii grupp krovi sistemy ABO s displaziei tazobedrennogo sustava.

On the basis of distribution of ABO blood groups among 963 sick children with dysplastic pathology of hip joint and 1402 Georgians from among the total population of the city of Tbilisi there have been obtained significant associations of 0 group with this pathology. The hypothesis about genetic community of these symptoms has been rejected. Phenotypic correlations have demonstrated that 0 group of blood promotes an expression of hereditary predisposition to the hip joint dysplastic pathology. Predisposition to this pathology is increased in case of coincidence of 0 group in the patient's mother and in the patient himself.

[Genetic and environmental factors in the families of children with dystrophic bone cysts]. / Geneticheskie i sredovye faktory v sem'iakh detei s distroficheskimi kostnymi kistami.

On the basis of data of 49 probands' families with dystrophic osseous, cyst, 12 probands' families with giant cell tumor and 55 children from the general population by means of clinical and multidimensional-genetical analysis (cluster, discriminant) have been revealed genetical and environmental factors, contributing to the formation of the osseous cysts in children. There have been developed the directions of the search of the "principal" environmental and genetical factors, determined the qualitative criteria of the factor significance, revealed the structures of the mutual connection of the significant factors and obtained their prognostication value definition.

[The correlations of dysplastic hip joint pathology with fetal breech presentation]. / Korreliatsii displasticheskoi patologii tazobedrennogo sustava s iagodichnym predlezhaniem ploda.

In the article are discussed the causes of hip joint instability at breech presentation. In the article are presented the results of examination of 116 probands with hip joint dysplasia, aged 5-15 years, and 69 breech presentation born probands, It has been carried out genetic-correlative analysis on the basis of population frequency and frequency among the probands' relatives, differentiated in accordance with the signs discussed. The principal cause of the hip joint dysplastic pathology formation at breech presentation is the mechanical factor.

[Structure of the correlations of genetic and environmental factors in congenital hip dislocation]. / Struktura vzaimosviazei geneticheskikh i sredovykh faktorov vrozhdennogo vyvikha bedra.

The aim of this paper was to determine the mechanisms of development or manifestations of the congenital dislocation of the hip by the method of multivariate analysis. The source of information were the family data about 300 children with congenital dislocation of the hip aged from 3 months to 15 years who had not been specially selected from those treated at the Centre and 300 children of the same age from unselected population. All the examinees were Georgians by nationality. Clinical methods of examination were employed. The results of the cluster analysis showed that the system of prognostic signs of the congenital dislocation of the hip consisted of 13 clusters in the experimental group (4 independent and 9 correlated) and of 13 clusters in the control group (5 independent and 8 correlated). The signs under investigation comprised the following groups of probable factors of the congenital dislocation of the hip: social-biological, geographical, obstetrical-gynecological, risk factors during the pregnancy, risk factors during the child birth on the mother's part, risk factors on the child's part, perinatal factors, postnatal factors, abnormalities of the child and its relatives. The obtained system of prognosis is well agreed with the biological mechanisms of the congenital dislocation of the hip. These data may be used for making perinatal and preclinical diagnosis, for raising the efficiency of medicogenetic consultations and for the initial orthopaedic prevention of the disease.

[Significance of genetic factors in the etiopathogenesis of allergic diseases]. / Znachimost' geneticheskikh faktorov v étiopatogeneze allergicheskikh zabolevanii.

It was established using the methods of genetic-mathematical analysis that the multifactorial model of heredity with uninterrupted distribution of liability is more adequate to the genetic system defining hereditary predisposition to allergoses.

[Hereditary hypermobility of the joints]. / O nasledovanii izbytochnoi podvizhnosti sustavov.

The authors applied clinico-genetic methods of analysis to work out the data concerning familial spread of hypermobility of the joints (567 inhabitants of Tbilisi, 302 children with congenital dislocation of the hip joint). A common genetic character of this pathology and congenital dislocation of the hip was established (88% of common genes). Approximate evaluations of relative contribution of the genetic component into the general dispersion (93%) and of the penetrance of the gene were obtained. A monogenous dominant type of inheritance was revealed.